Search strategy G for: "UK malaria treatment guidelines" Please refer to the Methods file for details of search methodology and deduplication. Topic G was simply defined as: (Congenital Malaria OR (malaria [all species] AND (pregnancy OR newborns OR infants OR breastfeeding))) AND diagnostic tests AND (sensitivity or specificity) Embase Classic+Embase Database name: Embase Classic + Embase Database platform: Ovid Dates of database coverage: 1947 to 2025 January 24 Date searched: 2025-01-27 Searched by: JF Number of hits: 663 EndNote import number: 2 Number of results after deduplication: 476 1 exp infant/ 1408931 2 (neonat* or neo-nat* or infant* or baby or babies or newborn* or new-born* or toddler or post-natal or pre-natal or antenatal or ANC or paediatric* or pediatric* or premature* or pre-mature* or preterm or pre-term).ti,ab. 2117121 3 exp breast feeding/ or mother/ or adolescent mother/ or expectant mother/ or exp pregnancy/ or pregnant woman/ or exp infectious pregnancy complication/ or pregnancy complication/ or maternal infection/ or puerperal infection/ 1207914 4 (mother* or maternal or breast feed* or breast fed* or pregnanc* or pregnant* or trimester* or obstetric*).ti,ab. 1426261 5 exp mother to child transmission/ or vertical transmission/ 21280 6 ((vertical or "mother-to-child") adj2 (disease or infect* or transmiss*)).ti,ab. 19562 7 or/1-6 [mother and infants] 3897184 8 malaria/ or exp cerebral malaria/ or exp malaria falciparum/ or placenta malaria/ or plasmodium knowlesi malaria/ or plasmodium malariae infection/ or plasmodium ovale malaria/ or plasmodium vivax malaria/ 122479 9 plasmodium/ or exp plasmodium falciparum/ or plasmodium knowlesi/ or plasmodium malariae/ or plasmodium ovale/ or plasmodium vivax/ 69502 10 (malaria* or plasmodium or p knowlesi or p ovale or p vivax or falciparum).ti,ab. 146869 11 or/8-10 [malaria all species] 173976 12 7 and 11 22202 13 congenital malaria/ 51 14 ((congenit* or gestation*) adj2 (malaria* or plasmodium or falciparum or p knowlesi or p ovale or p vivax)).ti,ab. 484 15 or/13-14 [congenital malaria] 496 16 12 or 15 22256 17 exp light microscopy/ or microscopy/ 288019 18 blood smear/ 21113 19 (((light or optical or simple) adj2 microscop*) or blood smear).ti,ab. 112132 20 rapid test/ or malaria rapid test/ 11190 21 ((rapid or diagnos* or "point of care" or home) adj2 test*).ti,ab. 162022 22 placenta/ 85731 23 fetus blood/ 9412 24 (placenta* or ((fetal or foetal or cord) adj2 blood*)).ti,ab. 230220 25 exp polymerase chain reaction/ 1322342 26 nucleic acid amplification techniques/ 14410 27 nucleic acid sequence based amplification/ 751 28 exp LAMP system/ 460 29 (polymerase chain reaction* or PCR* or qPCR* or reverse transcriptase PCR* or NAAT or NASBA or self-sustained sequence replicat* or isothermal amplif* or LAMP or primer or primers).ti,ab. 1288781 30 or/17-29 2461427 31 "sensitivity and specificity"/ 527801 32 exp reference value/ 160173 33 exp diagnosis/ 9380630 34 (accurac* or false positive* or false negative* or false rate* or screen positive* or likelihood or probabilit* or "detection rate*").tw,kw. or (receiver operat* or roc or sensitiv* or specificity or reference value* or accura* or reliab*).tw. or ((observer adj variation*) or (predictive adj3 value*) or "multiples of the median").tw. or (diagnosis or performance or MoM).tw,kf. 8889760 35 or/31-34 [sensitivity or specificity] 14938064 36 16 and 30 and 35 3003 37 limit 36 to yr="2021 -Current" 664 38 remove duplicates from 37 663 Global Health Database name: Global Health Database platform: Ovid Dates of database coverage: 1910 to 2025 Week 04 Date searched: 2025-01-27 Searched by: JF Number of hits: 160 EndNote import number: 3 Number of results after deduplication: 28 1 exp infants/ 178760 2 (neonat* or neo-nat* or infant* or baby or babies or newborn* or new-born* or toddler or post-natal or pre-natal or antenatal or ANC or paediatric* or pediatric* or premature* or pre-mature* or preterm or pre-term).ti,ab. 323261 3 exp breast feeding/ or mothers/ or pregnancy/ or pregnant women/ or pregnant adolescents/ or pregnancy complications/ 194335 4 (mother* or maternal or breast feed* or breast fed* or pregnanc* or pregnant* or trimester* or obstetric*).ti,ab. 268259 5 exp vertical transmission/ or transmammary transmission/ 10841 6 ((vertical or "mother-to-child") adj2 (disease or infect* or transmiss*)).ti,ab. 9700 7 or/1-6 [maternal and infants] 494102 8 plasmodium/ or plasmodium falciparum/ or plasmodium knowlesi/ or plasmodium malariae/ or plasmodium ovale/ or plasmodium vivax/ 126886 9 malaria/ or airport malaria/ or blackwater fever/ or cerebral malaria/ or falciparum malaria/ or malariae malaria/ or ovale malaria/ or vivax malaria/ 102888 10 (malaria* or plasmodium or p knowlesi or p ovale or p vivax or falciparum).ti,ab. 133558 11 or/8-10 [malaria all species] 137750 12 7 and 11 12302 13 ((congenit* or gestation*) adj2 (malaria* or plasmodium or falciparum or p knowlesi or p ovale or p vivax)).ti,ab. 504 14 12 or 13 [congenital malaria] 12366 15 microscopy/ 6118 16 (((light or optical or simple) adj2 microscop*) or blood smear).ti,ab. 11724 17 ((rapid or diagnos* or "point of care" or home) adj2 test*).ti,ab. 35184 18 placenta/ 10830 19 cord blood/ 4851 20 (placenta* or ((fetal or foetal or cord) adj2 blood*)).ti,ab. 23301 21 exp polymerase chain reaction/ 82077 22 (polymerase chain reaction* or PCR* or qPCR* or reverse transcriptase PCR* or NAAT or NASBA or self-sustained sequence replicat* or isothermal amplif* or LAMP or primer or primers).ti,ab. 257787 23 or/15-22 [diagnostic tests] 323025 24 exp diagnosis/ 274191 25 (accurac* or false positive* or false negative* or false rate* or screen positive* or likelihood or probabilit* or "detection rate*" or receiver operat* or roc or sensitiv* or specificity or reference value* or accura* or reliab* or (observer adj variation*) or (predictive adj3 value*) or "multiples of the median" or diagnosis or performance or MoM).tw. 1063768 26 or/24-25 [sensitivity and specificity] 1065065 27 14 and 23 and 26 789 28 limit 27 to yr="2021 -Current" 160 29 remove duplicates from 28 160 Medline ALL Database name: Medline ALL Database platform: Ovid Dates of database coverage: 1946 to January 24, 2025 Date searched: 2025-01-27 Searched by: JF Number of hits: 329 EndNote import number: 1 Number of results after deduplication: 325 1 exp Infant/ 1298386 2 (neonat* or neo-nat* or infant* or baby or babies or newborn* or new-born* or toddler or post-natal or pre-natal or antenatal or ANC or paediatric* or pediatric* or premature* or pre-mature* or preterm or pre-term).ti,ab. 1473692 3 exp Breast Feeding/ or Mothers/ or exp Pregnancy/ or Pregnant Women/ or pregnancy complications/ or pregnancy complications, infectious/ or pregnancy complications, parasitic/ or puerperal infection/ 1118250 4 (mother* or maternal or breast feed* or breast fed* or pregnanc* or pregnant* or trimester* or obstetric*).ti,ab. 1026613 5 Infectious Disease Transmission, Vertical/ 19490 6 ((vertical or "mother-to-child") adj2 (disease or infect* or transmiss*)).ti,ab. 15906 7 or/1-6 3138068 8 plasmodium/ or Plasmodium falciparum/ or plasmodium knowlesi/ or plasmodium malariae/ or plasmodium ovale/ or plasmodium vivax/ or malaria/ or malaria, vivax/ or exp Malaria, Falciparum/ or malaria, cerebral/ 93606 9 (malaria* or plasmodium or p knowlesi or p ovale or p vivax or falciparum).ti,ab. 118022 10 or/8-9 [malaria all species] 126481 11 7 and 10 19266 12 ((congenit* or gestation*) adj2 (malaria* or plasmodium or falciparum or p knowlesi or p ovale or p vivax)).ti,ab. 370 13 11 or 12 [non-falciparum] 19286 14 Microscopy/ 48151 15 (((light or optical or simple) adj2 microscop*) or blood smear).ti,ab. 89973 16 Rapid Diagnostic Tests/ 175 17 ((rapid or diagnos* or "point of care" or home) adj2 test*).ti,ab. 112295 18 Placenta/ 63696 19 Fetal Blood/ 32597 20 (placenta* or ((fetal or foetal or cord) adj2 blood*)).ti,ab. 158319 21 exp Polymerase Chain Reaction/ 470523 22 (polymerase chain reaction* or PCR* or qPCR* or reverse transcriptase PCR* or NAAT or NASBA or self-sustained sequence replicat* or isothermal amplif* or LAMP or primer or primers).ti,ab. 941081 23 or/14-22 1518191 24 exp "Sensitivity and Specificity"/ or Likelihood Functions/ or exp Reference Values/ or exp Diagnosis/ or (accurac* or false positive* or false negative* or false rate* or screen positive* or likelihood or probabilit* or "detection rate*").tw,kw. or (receiver operat* or roc or sensitiv* or specificity or reference value* or accura* or reliab*).tw. or ((observer adj variation*) or (predictive adj3 value*) or "multiples of the median").tw. or (diagnosis or performance or MoM).tw,kw. 14185039 25 13 and 23 and 24 2336 26 limit 25 to yr="2021 -Current" 330 27 remove duplicates from 26 329 Web of Science Core Content Database name: Web of Science Core Content This contains the following databases which were searched simultaneously: • Science Citation Index Expanded (SCI-EXPANDED) • Social Sciences Citation Index (SSCI) • Arts & Humanities Citation Index (AHCI) • Conference Proceedings Citation Index - Science (CPCI-S) • Conference Proceedings Citation Index - Social Science & Humanities (CPCI-SSH) • Emerging Sources Citation Index (ESCI) Database platform: Clarivate Analytics Web of Science Dates of database coverage: • SCI-EXPANDED 1970-present • SSCI 1970-present • AHCI 1975-present • CPCI-S 1990-present • CPCI-SSH 1990-present • ESCI 2019-present Data updated 2025-01-25 Date searched: 2025-01-27 Searched by: JF Number of hits: 160 EndNote import number: 4 Number of results after deduplication: 14 1: TI=(neonat* or neo-nat* or infant* or "baby" or "babies" or newborn* or new-born* or "toddler" or "post-natal" or "pre-natal" or "antenatal" or "ANC" or paediatric* or pediatric* or premature* or pre-mature* or "preterm" or "pre-term") or AB=(neonat* or neo-nat* or infant* or "baby" or "babies" or newborn* or new-born* or "toddler" or "post-natal" or "pre-natal" or "antenatal" or "ANC" or paediatric* or pediatric* or premature* or pre-mature* or "preterm" or "pre-term") Results: 1497794 2: TI=(mother* or "maternal" or breast feed* or breast fed* or pregnanc* or pregnant* or trimester* or obstetric*) or AB=(mother* or "maternal" or breast feed* or breast fed* or pregnanc* or pregnant* or trimester* or obstetric*) Results: 1069904 3: TI=(("vertical" or "mother-to-child") NEAR/2 ("disease" or infect* or transmiss*)) or AB=(("vertical" or "mother-to-child") NEAR/2 ("disease" or infect* or transmiss*)) Results: 16462 4: #3 OR #2 OR #1 Results: 2295363 5: TI=(malaria* or "plasmodium" or "p knowlesi" or "p ovale" or "p vivax" or "falciparum") or AB=(malaria* or "plasmodium" or "p knowlesi" or "p ovale" or "p vivax" or "falciparum") Results: 118162 6: #5 AND #4 Results: 9358 7: TI=((congenit* or gestation*) NEAR/2 (malaria* or "plasmodium" or "falciparum" or "p knowlesi" or "p ovale" or "p vivax")) or AB=((congenit* or gestation*) NEAR/2 (malaria* or "plasmodium" or "falciparum" or "p knowlesi" or "p ovale" or "p vivax")) Results: 303 8: #7 OR #6 Results: 9430 9: TI=((("light" or "optical" or "simple") NEAR/2 microscop*) or "blood smear") or AB=((("light" or "optical" or "simple") NEAR/2 microscop*) or "blood smear") Results: 205926 10: TI=(("rapid" or diagnos* or "point of care" or "home") NEAR/2 test*) or AB=(("rapid" or diagnos* or "point of care" or "home") NEAR/2 test*) Results: 145526 11: TI=(placenta* or (("fetal" or "foetal" or "cord") NEAR/2 blood*)) or AB=(placenta* or (("fetal" or "foetal" or "cord") NEAR/2 blood*)) Results: 165138 12: TI=("polymerase chain reaction*" or PCR* or qPCR* or "reverse transcriptase PCR*" or NAAT or NASBA or "self-sustained sequence replicat*" or "isothermal amplif*" or "LAMP" or "primer" or "primers") or AB=("polymerase chain reaction*" or PCR* or qPCR* or "reverse transcriptase PCR*" or NAAT or NASBA or "self-sustained sequence replicat*" or "isothermal amplif*" or "LAMP" or "primer" or "primers") Results: 1006547 13: #9 OR #10 OR #11 OR #12 Results: 1490537 14: TS=(accurac* or "false positive*" or "false negative*" or "false rate*" or "screen positive*" or "likelihood" or probabilit* or "detection rate*" or "receiver operat*" or "roc" or sensitiv* or "specificity" or "reference value*" or accura* or reliab* or ("observer" NEAR/1 variation*) or ("predictive" NEAR/3 value*) or "multiples of the median" or "diagnosis" or "performance" or "MoM") Results: 15325128 15: #14 AND #13 AND #8 Results: 646 16: #15 Timespan: 2021-01-01 to 2025-12-31 Results: 160