Search strategy A for: "UK malaria treatment guidelines" Please refer to the Methods file for details of search methodology and deduplication. Topic A was simply defined as: Malaria [all species] AND (anti-malaria drugs OR treatment failure) AND randomised controlled trials Embase Classic+Embase Database name: Embase Classic + Embase Database platform: Ovid Dates of database coverage: 1947 to 2025 January 28 Date searched: 2025-01-29 Searched by: JF Number of hits: 435 EndNote import number: 2 Number of results after deduplication: 153 1 malaria/ or exp cerebral malaria/ or exp malaria falciparum/ or placenta malaria/ or plasmodium knowlesi malaria/ or plasmodium malariae infection/ or plasmodium ovale malaria/ or plasmodium vivax malaria/ 122532 2 plasmodium/ or exp plasmodium falciparum/ or plasmodium knowlesi/ or plasmodium malariae/ or plasmodium ovale/ or plasmodium vivax/ 69526 3 (malaria* or plasmodium or p knowlesi or p ovale or p vivax or falciparum).ti,ab. 146938 4 or/1-3 [malaria] 174046 5 antimalarial agent/ 31349 6 artemisinin derivative/ 3405 7 artesunate/ 7786 8 artemether plus benflumetol/ 3657 9 artemether/ 3491 10 (atovaquone/ and proguanil/) or atovaquone plus proguanil/ 2320 11 quinine/ or quinine derivative/ 21317 12 mefloquine/ 8429 13 chloroquine/ 51175 14 primaquine/ 7317 15 (antimalarial* or anti-malarial* or artemisinin* or artesunate or ((artemether or benflumetol) adj2 lumefantrine) or riamet or coartem or ((dihydroartemisinin or artenimol) adj2 piperaquine) or eurartesim or (atovaquone adj2 proguanil) or malarone or quinine or mefloquine or chloroquine or primaquine or tafenoquine or Arakoda or Krintafel).ti,ab,rn. 111897 16 or/5-15 [drugs] 122870 17 treatment failure/ or "lack of drug effect"/ 202303 18 recurrent disease/ 237167 19 exp reinfection/ 39411 20 relapse/ or recrudescence/ 193354 21 (fail* or recurr* or reinfect* or relaps* or recrudesc*).ti,ab. 3407300 22 or/17-21 [treatment failure] 3546371 23 16 or 22 3656977 24 exp randomized controlled trial/ 865884 25 controlled clinical trial/ 442137 26 randomized.ab. 975427 27 placebo.ab. 379920 28 randomly.ab. 598248 29 trial.ti. 454737 30 or/24-29 2158969 31 (rat or rats or mouse or mice or swine or porcine or murine or sheep or lambs or pigs or piglets or rabbit or rabbits or cat or cats or dog or dogs or cattle or bovine or monkey or monkeys or trout or marmoset$1).ti. and animal experiment/ 1273935 32 animal experiment/ not (human experiment/ or human/) 2684801 33 31 or 32 2764162 34 30 not 33 [RCTs] 2026843 35 4 and 23 and 34 4186 36 limit 35 to yr="2021 -Current" 437 37 remove duplicates from 36 435 Global Health Database name: Global Health Database platform: Ovid Dates of database coverage: 1910 to 2025 Week 04 Date searched: 2025-01-29 Searched by: JF Number of hits: 270 EndNote import number: 3 Number of results after deduplication: 44 1 plasmodium/ or plasmodium falciparum/ or plasmodium knowlesi/ or plasmodium malariae/ or plasmodium ovale/ or plasmodium vivax/ 126886 2 malaria/ or airport malaria/ or blackwater fever/ or cerebral malaria/ or falciparum malaria/ or malariae malaria/ or ovale malaria/ or vivax malaria/ 102888 3 (malaria* or plasmodium or p knowlesi or p ovale or p vivax or falciparum).ti,ab. 133558 4 or/1-3 [malaria] 137750 5 antimalarials/ 29343 6 artemisinin/ 4979 7 artesunate/ 2384 8 artemether/ 1852 9 atovaquone/ and proguanil/ 378 10 quinine/ 8484 11 mefloquine/ 2334 12 chloroquine/ 11364 13 primaquine/ 2059 14 (antimalarial* or anti-malarial* or artemisinin* or artesunate or ((artemether or benflumetol) adj2 lumefantrine) or riamet or coartem or ((dihydroartemisinin or artenimol) adj2 piperaquine) or eurartesim or (atovaquone adj2 proguanil) or malarone or quinine or mefloquine or chloroquine or primaquine or tafenoquine or Arakoda or Krintafel).ti,ab. 44843 15 or/5-14 [drugs] 49801 16 treatment failure/ 10766 17 reinfection/ 6454 18 relapse/ 33353 19 (fail* or recurr* or reinfect* or relaps* or recrudesc*).ti,ab. 260307 20 or/16-19 [treatment failure] 262064 21 15 or 20 304017 22 randomized controlled trials/ 71407 23 randomized.ab. 114223 24 placebo.ab. 48869 25 randomly.ab. 125504 26 trial.ti. 52163 27 or/22-26 267512 28 exp animals/ not (man/ or human.sh.) 1088839 29 27 not 28 224052 30 4 and 21 and 29 2348 31 limit 30 to yr="2021 -Current" 270 32 remove duplicates from 31 270 Medline ALL Database name: Medline ALL Database platform: Ovid Dates of database coverage: 1946 to January 28, 2025 Date searched: 2025-01-29 Searched by: JF Number of hits: 382 EndNote import number: 1 Number of results after deduplication: 369 1 plasmodium/ or Plasmodium falciparum/ or plasmodium knowlesi/ or plasmodium malariae/ or plasmodium ovale/ or plasmodium vivax/ or malaria/ or malaria, vivax/ or exp Malaria, Falciparum/ or malaria, cerebral/ 93651 2 (malaria* or plasmodium or p knowlesi or p ovale or p vivax or falciparum).ti,ab. 118109 3 1 or 2 [malaria all species] 126568 4 Antimalarials/ 30353 5 Artemisinins/ 8083 6 Artesunate/ 2242 7 artemether/ or artemether, lumefantrine drug combination/ 1705 8 Atovaquone/ and Proguanil/ 372 9 Quinine/ 6775 10 Mefloquine/ 2249 11 Chloroquine/ 15743 12 Primaquine/ 2185 13 (antimalarial* or anti-malarial* or artemisinin* or artesunate or ((artemether or benflumetol) adj2 lumefantrine) or riamet or coartem or ((dihydroartemisinin or artenimol) adj2 piperaquine) or eurartesim or (atovaquone adj2 proguanil) or malarone or quinine or mefloquine or chloroquine or primaquine or tafenoquine or Arakoda or Krintafel).ti,ab,rn. 71557 14 treatment failure/ 38024 15 recurrence/ or reinfection/ 206252 16 (fail* or recurr* or reinfect* or relaps* or recrudesc*).ti,ab. 2233643 17 or/4-16 [drugs or treatment failure] 2372021 18 randomized controlled trial.pt. 631246 19 controlled clinical trial.pt. 95682 20 randomized.ab. 678358 21 placebo.ab. 255726 22 clinical trials as topic.sh. 204271 23 randomly.ab. 452081 24 trial.ti. 328185 25 or/18-24 1658831 26 exp animals/ not humans.sh. 5301552 27 25 not 26 [RCTs] 1529153 28 3 and 17 and 27 3414 29 limit 28 to yr="2021 -Current" 385 30 remove duplicates from 29 382 Web of Science Core Content Database name: Web of Science Core Content This contains the following databases which were searched simultaneously: • Science Citation Index Expanded (SCI-EXPANDED) • Social Sciences Citation Index (SSCI) • Arts & Humanities Citation Index (AHCI) • Conference Proceedings Citation Index - Science (CPCI-S) • Conference Proceedings Citation Index - Social Science & Humanities (CPCI-SSH) • Emerging Sources Citation Index (ESCI) Database platform: Clarivate Analytics Web of Science Dates of database coverage: • SCI-EXPANDED 1970-present • SSCI 1970-present • AHCI 1975-present • CPCI-S 1990-present • CPCI-SSH 1990-present • ESCI 2019-present Data updated 2025-01-26 Date searched: 2025-01-29 Searched by: JF Number of hits: 296 EndNote import number: 4 Number of results after deduplication: 17 1: TI=(malaria* or "plasmodium" or "p knowlesi" or "p ovale" or "p vivax" or "falciparum") or AB=(malaria* or "plasmodium" or "p knowlesi" or "p ovale" or "p vivax" or "falciparum") Results: 118166 2: TI=(antimalarial* or anti-malarial* or artemisinin* or "artesunate" or (("artemether" or "benflumetol") NEAR/2 "lumefantrine") or "riamet" or "coartem" or (("dihydroartemisinin" or "artenimol") NEAR/2 "piperaquine") or "eurartesim" or ("atovaquone" NEAR/2 "proguanil") or "malarone" or "quinine" or "mefloquine" or "chloroquine" or "primaquine" or "tafenoquine" or "Arakoda" or "Krintafel") or AB=(antimalarial* or anti-malarial* or artemisinin* or "artesunate" or (("artemether" or "benflumetol") NEAR/2 "lumefantrine") or "riamet" or "coartem" or (("dihydroartemisinin" or "artenimol") NEAR/2 "piperaquine") or "eurartesim" or ("atovaquone" NEAR/2 "proguanil") or "malarone" or "quinine" or "mefloquine" or "chloroquine" or "primaquine" or "tafenoquine" or "Arakoda" or "Krintafel") Results: 58692 3: TI=(fail* or recurr* or reinfect* or relaps* or recrudesc*) or AB=(fail* or recurr* or reinfect* or relaps* or recrudesc*) Results: 3004576 4: #3 OR #2 Results: 3058389 5: AB=("randomized" or "placebo" or "randomly") or TI=("trial") Results: 1553697 6: TI=("rat" or "rats" or "mouse" or "mice" or "swine" or "porcine" or "murine" or "sheep" or "lambs" or "pigs" or "piglets" or "rabbit" or "rabbits" or "cat" or "cats" or "dog" or "dogs" or "cattle" or "bovine" or "monkey" or "monkeys" or "trout" or marmoset*) NOT TS=("man" or "human") Results: 2530928 7: #5 not #6 Results: 1478781 8: #7 AND #4 AND #1 Results: 2117 9: #8 Timespan: 2021-01-01 to 2025-12-31 Results: 296