10.17037/DATA.00004932
Dataset to reproduce the statistical analysis reported in the manuscript titled "A predictive score to identify high transmission-risk households of individuals newly-diagnosed with pulmonary tuberculosis in rural South Africa".
This secondary data analysis used data collected as part of TB household case-contact study (Africa Health Research Institute (AHRI) Household Contact study) investigating M. tuberculosis (MTB) transmission in rural KwaZulu-Natal, South Africa. A key focus of the study was to better understand how HIV status, antiretroviral treatment (ART), and symptom presentation affect infectiousness of the index person with TB. The study recruited adults with bacteriologically-confirmed pulmonary TB from routine health services and tested their child household contacts (aged 2-14 years) for evidence of immunoreactivity to MTB using QuantiFERON TB Gold plus assay.
By comparing prevalence of MTB immunoreactivity among children exposed to index cases with different HIV/ART statuses and symptom profiles, the research aimed to quantify within-household transmission risk and inform TB screening strategies.
| Variable name | Variable description | Answer code | Answer label | Variable type |
| id | Study participant identifier | . | . | Numeric |
| sex | Sex of index person with TB | String | ||
| 1 | Female | |||
| 2 | Male | |||
| hiv | HIV status of index PWTB | Factor | ||
| 0 | Negative | |||
| 1 | Positive | |||
| education | Has participant completed high school | Factor | ||
| 0 | No | |||
| 1 | Yes | |||
| index_tbpast | Index person with TB reported a previous history of TB | Factor | ||
| 0 | No | |||
| 1 | Yes | |||
| trace_nhls | Result of diagnostic sputum Xpert Ultra test conducted as part of routine care at facility | Factor | ||
| 0 | Trace | |||
| 1 | Positive | |||
| cavitation | Evidence of cavitation on CXR | Factor | ||
| 0 | No | |||
| 1 | Yes | |||
| cxr_activetb | Evidence of active TB on CXR | Factor | ||
| 0 | No | |||
| 1 | Yes | |||
| primary_outcome | Household MTB immunoreactivity defined as least one child contact with positive QFT plus assay | Factor | ||
| 0 | No | |||
| 1 | Yes | |||
| sens1_outcome | Household Mtb immunoreactivity defined as positive if (i) among households with four or more enrolled children, at least two children had a positive QFT-Plus result and (ii) among households with less than four enrolled children, at least one child had a positive QFT-Plus result | Factor | ||
| 0 | No | |||
| 1 | Yes | |||
| sens2_outcome | Restricted to children aged 10 and below: household Mtb immunoreactivity defined as positive if at least one child had a positive QFT-Plus assay result | Factor | ||
| 0 | No | |||
| 1 | Yes |