10.17037/DATA.00004678
This dataset comprises individual-level data of a subset of participants from a longitudinal study nested within the Entebbe Mother and Baby Study (EMaBS) birth cohort, based in Entebbe municipality, Uganda. Data were drawn from three studies that these participants took part in, where samples were collected: pre-pandemic samples (2014–2016) collected during a blood pressure study; pandemic-era samples collected during the POPVAC C trial (2020–2021) (ISRCTN32849447), which evaluated the impact of BCG revaccination on vaccine responses; and samples from the CoHost study (2021–2022), a 12-month longitudinal follow-up assessing SARS-CoV-2 infection and exposure from participants in the POPVAC B randomised controlled trial. The study aimed to analyse temporal trends in SARS-CoV-2 seropositivity in Ugandan adolescents using pre-pandemic (2014-2016) and pandemic-era samples (2020-2022). We utilised previously stored demographic and clinical data, along with bio-banked samples from these three studies.
The following variables are contained in the dataset.
| Variable Name | Variable Label | Answer Label | Answer Code | Variable Type |
| rec_id_1 | CoHost ID (unlinked) | Open ended | String | |
| od_10yrs | Optical density at 10 years | Open ended | Numeric | |
| od_screening_POPVAC | Optical density at POPVAC screening | Open ended | Numeric | |
| od_week4_POPVAC | Optical density at POPVAC week 4 | Open ended | Numeric | |
| od_week8_POPVAC | Optical density at POPVAC week 8 | Open ended | Numeric | |
| od_week52_POPVAC | Optical density at POPVAC week 52 | Open ended | Numeric | |
| od_visit2_CoHost | Optical density at CoHost visit 2 | Open ended | Numeric | |
| od_visit3_CoHost | Optical density at CoHost visit 3 | Open ended | Numeric | |
| rec_sex | Participant sex | Numeric | ||
| Male | 1 | |||
| Female | 2 | |||
| rec_age | Age in years | 15 to 17 | Numeric | |
| rec_popvactrial | Has participant taken part in the POPVAC C trial? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| enr_cont | 1. To your knowledge, have you had contact with anyone with suspected or confirmed COVID-19 | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| enr_expcov | 2. Since the beginning of last year (2020) have you experienced a COVID-like illness | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Not sure | 99 | |||
| enr_mcov | If Yes, in which month did this start? | Numeric | ||
| January | 1 | |||
| February | 2 | |||
| March | 3 | |||
| April | 4 | |||
| May | 5 | |||
| June | 6 | |||
| July | 7 | |||
| August | 8 | |||
| September | 9 | |||
| October | 10 | |||
| November | 11 | |||
| December | 12 | |||
| enr_ycov | If Yes, in which year did this start? | Integer | ||
| 2019 | 2019 | |||
| 2020 | 2020 | |||
| 2021 | 2021 | |||
| 2022 | 2022 | |||
| 2023 | 2023 | |||
| enr_ldcov | Number of days | Open ended | Numeric | |
| enr_lwcov | Number of weeks | Open ended | Numeric | |
| enr_lmcov | Number of months | Open ended | Numeric | |
| enr_duration_cov | If Yes, how long did the illness last? | Numeric | ||
| Days {enr_ldcov} | 1 | |||
| Weeks {enr_lwcov} | 2 | |||
| Months {enr_lmcov} | 3 | |||
| Missing | . | |||
| enr_ongcov | If Yes, is the illness still ongoing? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| enr_actcov | If yes, did the illness affect your ability to undertake your normal daily activities? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| enr_hspcov | If Yes, did the illness require you to be hospitalised? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| enr_oxycov | If Yes, did the illness require you to be put on oxygen? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| enr_covtst | If Yes, did you have a COVID test? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| enr_rsltcov | If Yes, what was the result of the COVID test? | Numeric | ||
| Negative | 1 | |||
| Positive | 2 | |||
| Not sure | 3 | |||
| Missing | . | |||
| enr_covvac | 3. Have you been vaccinated against SARS-CoV-2? | Numeric | ||
| No | 0 | |||
| Yes, partial (first jab) | 1 | |||
| Yes, fully | 2 | |||
| fever | Any history of fever? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| runny | History of runny nose? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| cough | History of cough? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| soreth | History of sore throat? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| shbrh | History of shortness of breath? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| taste | History of loss of taste or smell? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| fatigue | History of fatigue? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| head | History of headache? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| mpains | History of muscle pains? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| othsp | Other symptom? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| enr_oth_spec | If Other Symptom, specify | Open ended | String | |
| enr_dothsp | If Yes, for how long have you had this symptom (in days)? | Open ended | String | |
| enr_medatt | 5. Did any of the above symptoms require you to seek medical attention? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Dont know | 99 | |||
| Missing | . | |||
| enr_misssch | 6. Did any of the above symptoms require you to miss school or interfer with daily activities? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Dont know | 99 | |||
| Missing | . | |||
| enr_reqhosp | 7. Did any of the above symptoms require you to be hospitalised? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Dont know | 99 | |||
| Missing | . | |||
| enr_reqoxyg | 8. Did any of the above symptoms make you require oxygen | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Dont know | 99 | |||
| Missing | . | |||
| enr_skinsh | Any examination abnormality on skin? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| enr_respsh | Any examination abnormality in the respiratory system? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| enr_cardsh | Any examination abnormality in the cardiovascular system? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| enr_gastsh | Any examination abnormality in the gastrointestinal system? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| enr_neursh | Any examination abnormality in the neurological system? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| enr_allergsh | Any examination abnormality that are eallergy related? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| enr_surgsh | Any significant surgery in the past? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| enr_othhissh | Other, specify | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| enr_respd | If any yes, give details | No responses present in data | String | |
| enr_cardd | If any yes, give details | No responses present in data | String | |
| enr_gastd | If any yes, give details | No responses present in data | Numeric | |
| enr_neurd | If any yes, give details | No responses present in data | Numeric | |
| enr_allergd | If any yes, give details | No responses present in data | String | |
| enr_surgd | If any yes, give details | No responses present in data | Numeric | |
| enr_othhisd | If any yes, give details | No responses present in data | String | |
| enr_peskin | Skin (no responses present in data) | Numeric | ||
| Abnormal | 0 | |||
| Normal | 1 | |||
| enr_peresp | Respiratory (no responses present in data) | Numeric | ||
| Abnormal | 0 | |||
| Normal | 1 | |||
| hiv_visitday | HIV test done at enrolment? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| hiv_det | HIV Determine test results | Numeric | ||
| Reactive | 1 | |||
| Non-reactive | 2 | |||
| hiv_hivresult | HIV final results if indeterminate complete HIV ELISA results and send to CDLS Laboratory | Numeric | ||
| Reactive | 1 | |||
| Non-reactive | 2 | |||
| Indeterminate | 3 | |||
| labvac_pat_vday_dose1 | Vaccination visit (dose 1) | Numeric | ||
| First Dose visit | 1 | |||
| Second dose visit (after 4 weeks) | 2 | |||
| Vaccination end point (4 weeks post Dose 2) | 3 | |||
| lab_vacc_1_dose1 | Is the Child eligible for COVID-19 dose 1? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| labvacc_adm_dose1 | Vaccine Administered? (dose 1) | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| labvac_vacc_dose1 | Which vaccine administered? (dose 1) | Numeric | ||
| Pfizer | 1 | |||
| Other | 2 | |||
| labvac_pat_vday_dose2 | Vaccination visit (dose 2) | Numeric | ||
| First Dose visit | 1 | |||
| Second dose visit (after 4 weeks) | 2 | |||
| Vaccination end point (4 weeks post Dose 2) | 3 | |||
| lab_vacc_dose2 | Is the Child eligible for COVID-19 dose 2? | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| labvacc_adm_dose2 | Vaccine Administered? (dose 2) | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| det | HIV Determine test results | Numeric | ||
| reactive | 1 | |||
| non-reactive | 2 | |||
| inconclusive | 3 | |||
| not done | 4 | |||
| Not applicable | 5 | |||
| hivresult | HIV final result | Numeric | ||
| reactive | 1 | |||
| non-reactive | 2 | |||
| inconclusive | 3 | |||
| not done | 4 | |||
| Not applicable | 5 |