10.17037/DATA.00004678
This dataset comprises individual-level data of a subset of participants from a longitudinal study nested within the Entebbe Mother and Baby Study (EMaBS) birth cohort, based in Entebbe municipality, Uganda. Data were drawn from three studies that these participants took part in, where samples were collected: pre-pandemic samples (2014–2016) collected during a blood pressure study; pandemic-era samples collected during the POPVAC C trial (2020–2021) (ISRCTN32849447), which evaluated the impact of BCG revaccination on vaccine responses; and samples from the CoHost study (2021–2022), a 12-month longitudinal follow-up assessing SARS-CoV-2 infection and exposure from participants in the POPVAC B randomised controlled trial. The study aimed to analyse temporal trends in SARS-CoV-2 seropositivity in Ugandan adolescents using pre-pandemic (2014-2016) and pandemic-era samples (2020-2022). We utilised previously stored demographic and clinical data, along with bio-banked samples from these three studies.
Previously stored demographic and clinical data, along with bio-banked samples, were used for this study. In the CoHost study, participants were administered a questionnaire capturing demographic information, medical history, SARS-CoV-2 exposure, and recent illness history, recorded using the research electronic data capture (REDCap) application.
Entebbe municipality, Uganda.
A subset of participants from a longitudinal study nested within the Entebbe Mother and Baby Study (EMaBS) birth cohort, based in Entebbe municipality, Uganda.
Direct identifiers have been removed from the data.
| Organisation | Ethics ID | Other information |
| Uganda Virus Research Institute | EMaBS | Approved 18 May 2022 |
SARS-CoV-2, Adolescents, COVID-19, Uganda, Longitudinal
English
| Project name | Funder/sponsor | Grant number | Other information |
| CoHost | Science for Africa Foundation | GCA/SARSCov2-2-20-002 | https://scienceforafrica.foundation/ |
| VAnguard | National Institute for Health Research (NIHR) | NIHR134531 |
| Forename | Surname | Faculty / Dept | Institution | Role |
| Ludoviko | Zirimenya | Vaccines Research Theme | MRC/UVRI & LSHTM Uganda Research Unit | Data Creator |
| Agnes | Natukunda | Faculty of Epidemiology and Population Health / Dept of Infectious Disease Epidemiology and International Health | London School of Hygiene & Tropical Medicine | Data Creator |
| Jacent | Nassuna | MRC/UVRI & LSHTM Uganda Research Unit | Data Creator | |
| Gyaviira | Nkurunungi | MRC/UVRI & LSHTM Uganda Research Unit | Data Creator | |
| Alison M. | Elliott | Faculty of Infectious and Tropical Diseases / Dept of Clinical Research | London School of Hygiene & Tropical Medicine | Data Creator |
| Emily | Webb | Faculty of Epidemiology and Population Health / Dept of Infectious Disease Epidemiology and International Health | London School of Hygiene & Tropical Medicine | Data Creator |
| Forename | Surname | Faculty / Dept | Institution | Role |
| Christopher | Zziwa | MRC/UVRI & LSHTM Uganda Research Unit | Researcher | |
| Caroline | Ninsiima | MRC/UVRI & LSHTM Uganda Research Unit | Researcher | |
| Christine | Kukundakwe | MRC/UVRI & LSHTM Uganda Research Unit | Researcher | |
| Milly | Namutebi | MRC/UVRI & LSHTM Uganda Research Unit | Researcher | |
| Gloria | Oduru | MRC/UVRI & LSHTM Uganda Research Unit | Researcher | |
| Denis | Nsubuga | MRC/UVRI & LSHTM Uganda Research Unit | Researcher | |
| Josephine | Tumusiime | MRC/UVRI & LSHTM Uganda Research Unit | Researcher | |
| Racheal | Nakyesige | MRC/UVRI & LSHTM Uganda Research Unit | Researcher | |
| Simon | Kimuda | MRC/UVRI & LSHTM Uganda Research Unit | Researcher | |
| Jennifer | Serwanga | MRC/UVRI & LSHTM Uganda Research Unit | Researcher | |
| Katie J | Doores | King’s College London | Researcher | |
| Anne | Wajja | MRC/UVRI & LSHTM Uganda Research Unit | Researcher |
| Filename | Description | Access status | Licence |
| CoHost_dataset | Individual-level data collected from a subset of participants from a longitudinal study nested within the Entebbe Mother and Baby Study (EMaBS) birth cohort | Controlled access | Data sharing agreement |
| CoHost_dataset_codebook | Codebook for CoHost dataset | Open access | Creative Commons Attribution (CCBY) |
| 4679_UserGuide | User guide for CoHost dataset (this document) | Open access | Creative Commons Attribution (CCBY) |