Data supporting “The effect of current helminth infection on vaccine responses among adolescents living in helminth-endemic islands of Lake Victoria, Uganda” – User Guide

Persistent identifier

10.17037/DATA.00003862

Description

The data contain anonymized individual-level records of 478 schoolchildren (aged 9-17 years) who participated in a randomized controlled trial investigating the effect of Schistosomiasis treatment on responses to a portfolio of vaccines, known as the POPVAC A trial. Helminth infections were assessed prior to vaccination to enable comparisons of vaccine-specific immune responses between infected and uninfected children, aiming to answer the question of whether helminth infection before vaccination affects responses observed following vaccination.

Data collection methods

Data on participant baseline characteristics were collected using a questionnaire. Helminth infections and responses to vaccine specific immune responses were laboratory generated.

Geographic regions

Koome Island of Lake Victoria, Uganda

Key dates

July 2019 to October 2020

Quality controls

Checks for missing data, out of range values and inconsistences were done regularly throughout the data collection period.

Population

Schoolchildren aged 9 to 17 years

Privacy

Personal identifying information such as participant initials, study identification numbers, school names have been removed from the dataset.

Ethics

Organisation Ethics ID Other information
Uganda Virus Research Institute GC/127/18/09/680, GC/127/19/05/664 Research Ethics Committee
London School of Hygiene and Tropical Medicine 16032 Observational/Interventions Research Ethics Committee
Uganda National Council for Science and Technology HS2486  
Uganda National Drug Authority CTA0093  

Keywords

Helminths, vaccination, immune responses

Language of written material

English

Project information

Project name Funder/sponsor Grant number
POPVAC Medical Research Council MR/R02118X/1
POPVAC Medical Research Council MC_PC_21034

Creators

Forename Surname Faculty / Dept Institution Role
Agnes Natukunda   MRC/UVRI and LSHTM Uganda Research Unit Data Creator
Ludoviko Zirimenya   MRC/UVRI and LSHTM Uganda Research Unit Data Creator
Gyaviira Nkurunungi   MRC/UVRI and LSHTM Uganda Research Unit Data Creator
Jacent Nassuuna   MRC/UVRI and LSHTM Uganda Research Unit Data Creator
Alison Elliott   MRC/UVRI and LSHTM Uganda Research Unit Data Creator
Emily Webb Infectious Disease Epidemiology London School of Hygiene & Tropical Medicine Data Creator

Associated roles

Ronald Nkangi1, Alex Mutebe1, Paul LAM Corstjens4, Govert J van Dam5

Forename Surname Faculty / Dept Institution Role
Ronald Nkangi   MRC/UVRI and LSHTM Uganda Research Unit Researcher
Alex Mutebe   MRC/UVRI and LSHTM Uganda Research Unit Data manager
Paul LAM Corstjens Department of Cell and Chemical Biology Leiden University Medical Center Researcher
Govert J Van Dam Department of Parasitology Leiden University Medical Center Researcher

File description

Filename Description Access status Licence
POPVAC_A_observational_analysis_data Contains variables on Schistosoma mansoni, hookworm and Strongyloides infection status, characteristics such as age and sex, vaccine immune responses to BCG, yellow fever, oral typhoid, HPV, tetanus, and diphtheria. Request access for all Data Sharing Agreement for request access
POPVAC_A_observational_data_codebook Codebook for the POPVAC A observational analysis dataset Open Creative Commons Attribution (CCBY)
3862_Userguide User guide for the POPVAC A observational analysis dataset (this document) Open Creative Commons Attribution (CCBY)