10.17037/DATA.00003862
The data contain anonymized individual-level records of 478 schoolchildren (aged 9-17 years) who participated in a randomized controlled trial investigating the effect of Schistosomiasis treatment on responses to a portfolio of vaccines, known as the POPVAC A trial. Helminth infections were assessed prior to vaccination to enable comparisons of vaccine-specific immune responses between infected and uninfected children, aiming to answer the question of whether helminth infection before vaccination affects responses observed following vaccination.
To access the data, requests must be made to the PI (Professor Alison Elliott). The request will be reviewed by the PI together with the POPVAC investigator team, in consultation with the POPVAC steering committee. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed.
The POPVAC A observational analysis dataset contains the following data variables.
| Variable name | Variable description | Answer label | Answer code | Variable type |
| age | age of participants at enrolment | Numeric | ||
| sex | Participant's sex | |||
| Male | 1 | Numeric | ||
| Female | 2 | |||
| immp1 | Received immunisations as a baby, or as a child before school | |||
| No | 0 | Numeric | ||
| Yes | 1 | |||
| Don't know | 98 | |||
| Missing | . | |||
| imms1 | Received any immunisations since starting school | |||
| No | 0 | Numeric | ||
| Yes | 1 | |||
| Don't know | 98 | |||
| Missing | . | |||
| vilb | Place of residence at birth | Numeric | ||
| Village | 1 | |||
| Town | 2 | |||
| City | 3 | |||
| Don't know | 99 | |||
| Missing | . | |||
| vil5 | Where lived for most of the time between birth and age five years | Numeric | ||
| Village | 1 | |||
| Town | 2 | |||
| City | 3 | |||
| Don't know | 99 | |||
| Missing | . | |||
| wmx | Times treated for worms in the last 12 months | Numeric | ||
| mrx | Whether treated for malaria in the last year | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Don't know | 98 | |||
| Missing | . | |||
| toi | Whether the household has its own toilet | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | . | |||
| trialarm | Trial arm | Numeric | ||
| Standard | 0 | |||
| Intensive | 1 | |||
| bcg_w0 | bcg administration at week0 | Numeric | ||
| Yes | 1 | |||
| Missing | . | |||
| yf_w4 | Yellow fever administration at week4 | Numeric | ||
| Yes | 1 | |||
| No | 0 | |||
| Missing | . | |||
| hpv_w4 | HPV administration at week4 | Numeric | ||
| Yes | 1 | |||
| No | 0 | |||
| Missing | . | |||
| ty1d1_w4 | 1st dose of oral typhoid at week4 | Numeric | ||
| Yes | 1 | |||
| No | 0 | |||
| Missing | . | |||
| ty1d2_w4 | 2nd dose of oral typhoid at week4 | Numeric | ||
| Yes | 1 | |||
| No | 0 | |||
| Missing | . | |||
| ty1d3_w4 | 3rd dose of oral typhoid at week4 | Numeric | ||
| Yes | 1 | |||
| No | 0 | |||
| Missing | . | |||
| hpv_w8 | hpv administration at week8 | Numeric | ||
| Yes | 1 | |||
| No | 0 | |||
| Missing | . | |||
| td_w28 | Tetanus and diphtheria administration at week28 | Numeric | ||
| Yes | 1 | |||
| No | 0 | |||
| Missing | . | |||
| hpv_w28 | hpv administration at week28 | Numeric | ||
| Yes | 1 | |||
| No | 0 | |||
| Missing | . | |||
| td_w52 | Tetanus and diphtheria administration at week52 | Numeric | ||
| Yes | 1 | |||
| No | 0 | |||
| Missing | . | |||
| caa_screening_caa | S.mansoni CAA concentration at screening, pg/ml | String | ||
| result_screening_caa | S.mansoni CAA result at screening | String | ||
| Indecisive | String | |||
| Negative | ||||
| Positive | ||||
| necres_screen | Necator americanus PCR resultat screening | String | ||
| Negative | ||||
| Positive | ||||
| smres_screen | S.mansoni PCR result at screening | String | ||
| Negative | ||||
| Positive | ||||
| ssres_screen | Strongyloides stercoralis PCR result at screening | String | ||
| Negative | ||||
| Positive | ||||
| pfal_res | Malaria PCR results at screening | String | ||
| Negative | ||||
| Positive | ||||
| qc_0 | Did BCG response result pass QC (≤83.333 SFUs/10^6 PBMCs) at week 0 | String | ||
| pass | ||||
| qc_8 | Did BCG response result pass QC (≤83.333 SFUs/10^6 PBMCs ) at week 8 | String | ||
| pass | ||||
| qc_52 | Did BCG response result pass QC (≤83.333 SFUs/10^6 PBMCs ) at week 8 | String | ||
| pass | ||||
| bmi | Body mass index | Numeric | ||
| sm_screening_caa_pcr | S.mansoni result at screening based on CAA and PCR | Numeric | ||
| Negative | 0 | |||
| Positive | 1 | |||
| drinking_w | Source of household drinking water | Numeric | ||
| Lake/spring | 1 | |||
| Well/Piped water | 2 | |||
| diet_score_days | Diet score based on days/week of food consumption | Numeric | ||
| tt_IgG_week28 | Tetanus toxoid-specific IgG at week 28, IU/ml | Numeric | ||
| dt_IgG_week28 | Diphtheria toxoid-specific IgG at week 28, IU/ml | Numeric | ||
| tt_IgG_week52 | Tetanus toxoid-specific IgG at week 52, IU/ml | Numeric | ||
| dt_IgG_week52 | Diphtheria toxoid-specific IgG at week 52, IU/ml | Numeric | ||
| bcg_week0 | IFN-gamma response to BCG at week 0 (SFUs per million PBMCs) | Numeric | ||
| bcg_week8 | IFN-gamma response to BCG at week 8 (SFUs per million PBMCs) | Numeric | ||
| bcg_week52 | IFN-gamma response to BCG at week 52 (SFUs per million PBMCs) | Numeric | ||
| yfprnt_50_wk0 | Yellow fever PRNT 50 titre at week 0 | Numeric | ||
| yfprnt_90_wk0 | Yellow fever PRNT 90 titre at week 0 | Numeric | ||
| yfprnt_50_wk8 | Yellow fever PRNT 50 titre at week 8 | Numeric | ||
| yfprnt_90_wk8 | Yellow fever PRNT 90 titre at week 8 | Numeric | ||
| yfprnt_50_wk52 | Yellow fever PRNT 50 titre at week 52 | Numeric | ||
| yfprnt_90_wk52 | Yellow fever PRNT 90 titre at week 52 | Numeric | ||
| typhi_igg_wk0 | S. typhi O:LPS-specific IgG at week 0, EU/ml | Numeric | ||
| typhi_igg_wk8 | S. typhi O:LPS-specific IgG at week 8, EU/ml | Numeric | ||
| typhi_igg_wk52 | S. typhi O:LPS-specific IgG at week 52, EU/ml | Numeric | ||
| hpv16_wk0 | HPV-16-specific IgG concentration at week 0, EU/ml | Numeric | ||
| hpv18_wk0 | HPV-18-specific IgG concentration at week 0, EU/ml | Numeric | ||
| hpv16_wk8 | HPV-16-specific IgG concentration at week 8, EU/ml | Numeric | ||
| hpv18_wk8 | HPV-18-specific IgG concentration at week 8, EU/ml | Numeric | ||
| hpv16_wk52 | HPV-16-specific IgG concentration at week 52, EU/ml | Numeric | ||
| hpv18_wk52 | HPV-18-specific IgG concentration at week 52, EU/ml | Numeric |