Data supporting "Does schistosome or malaria exposure contribute to urban-rural differences in vaccine responses in Uganda? A causal mediation analysis using data from three linked randomised controlled trials." – Data codebook

Persistent identifier

10.17037/DATA.00003761

Description

This dataset comprises individual-level data from participants in the POPVAC series of three randomised controlled trials. POPVAC A was conducted among schoolchildren from Koome islands, Uganda (a schistosomiasis-endemic setting), POPVAC B was conducted among schoolchildren from Jinja district, Uganda (a malaria-endemic setting), POPVAC C was conducted among schoolchildren from Entebbe, Uganda (a lower infection prevalence setting).

Data access statement

To access the data, requests must be made to the PI (Professor Alison Elliott). The request will be reviewed by the PI together with the POPVAC investigator team, in consultation with the POPVAC steering committee. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed.

Data codebook

The following variables are contained within the POPVAC settings dataset.

Variable name Variable description Answer label Answer code Variable type
study POPVAC trial indicator     String
    Trial A Trial A  
    Trial B Trial B  
    Trial C Trial C  
sex Participant's sex     String
    Female Female  
    Male Male  
age Participant's age in years (age placed in categories where fewer participants)     Numeric
    Age 9 9  
    Age 10 10  
    Age 11 11  
    Age 12 12  
    Age 13 13  
    Age 14 14  
    Age 15 15  
    Age 16-17 16-17  
bcg_w0 BCG vaccine administered at week 0     String
    Yes 1  
    No 0  
    Missing .  
yf_w4 Yellow fever vaccine administered at week 4     String
    Yes 1  
    No 0  
    Missing .  
hpv_w4 HPV vaccine administered at week 4     String
    Yes 1  
    No 0  
    Missing .  
hpv_w8 HPV vaccine administered at week 8     String
    Yes 1  
    No 0  
    Missing .  
hpv_w28 HPV vaccine administered at week 28     String
    Yes 1  
    No 0  
    Missing .  
atleastone_ot_dose At least one dose of oral typhoid administered at week 4     String
    Yes 1  
    No 0  
    Missing .  
td_w28 Tetanus-diphtheria administered at week 28     String
    Yes 1  
    No 0  
    Missing .  
tt_igg_baseline Tetanus toxoid-specific IgG at trial "baseline" (baseline for Td), IU/ml Continuous   Numeric
tt_igg_week52 Tetanus toxoid-specific IgG at week 52, IU/ml Continuous   Numeric
dt_igg_baseline Diphtheria toxoid-specific IgG at trial "baseline" (baseline for Td), IU/ml Continuous   Numeric
dt_igg_week52 Diphtheria toxoid-specific IgG at week 52, IU/ml Continuous   Numeric
bcg_ifng_baseline IFN-gamma response to BCG at baseline0 (SFUs per million PBMCs) Continuous   Numeric
bcg_ifng_week8 IFN-gamma response to BCG at week 8 (SFUs per million PBMCs) Continuous   Numeric
bcg_ifng_week52 IFN-gamma response to BCG at week 52 (SFUs per million PBMCs) Continuous   Numeric
yf_50_week0 Yellow fever PRNT 50 titre at week 0 Continuous   Numeric
yf_50_week8 Yellow fever PRNT 50 titre at week 8 Continuous   Numeric
yf_50_week52 Yellow fever PRNT 50 titre at week 52 Continuous   Numeric
yf_90_week0 Yellow fever PRNT 90 titre at week 0 Continuous   Numeric
yf_90_week8 Yellow fever PRNT 90 titre at week 8 Continuous   Numeric
yf_90_week52 Yellow fever PRNT 90 titre at week 52 Continuous   Numeric
typhi_igg_week0 S. typhi O:LPS-specific IgG at week 0, EU/ml Continuous   Numeric
typhi_igg_week8 S. typhi O:LPS-specific IgG at week 8, EU/ml Continuous   Numeric
typhi_igg_week52 S. typhi O:LPS-specific IgG at week 52, EU/ml Continuous   Numeric
hpv16_wk0 HPV-16-specific IgG concentration at week 0, EU/ml Continuous   Numeric
hpv16_wk8 HPV-16-specific IgG concentration at week 8, EU/ml Continuous   Numeric
hpv16_wk52 HPV-16-specific IgG concentration at week 52, EU/ml Continuous   Numeric
hpv18_wk0 HPV-18-specific IgG concentration at week 0, EU/ml Continuous   Numeric
hpv18_wk8 HPV-18-specific IgG concentration at week 8, EU/ml Continuous   Numeric
hpv18_wk52 HPV-18-specific IgG concentration at week 52, EU/ml Continuous   Numeric
caa_result_baseline_num S. mansoni CAA result at baseline     String
    Positive Positive  
    Negative Negative  
sea_ug_ml Schistosoma egg antigen-specific IgG, ug/ml Continuous   Numeric
pfal_res_baseline_num Malaria status at baseline, PCR     String
    Positive Positive  
    Negative Negative  
PfMSP2_IgG_titre PfMSP2 IgG titre at baseline Continuous   Numeric
PfAMA1_IgG_titre PfAMA1 IgG titre at baseline Continuous   Numeric
bmi Body mass index Continuous   Numeric
treated_worm_12m Treated for worms in the last 12 months (reported at enrolment)     String
    Yes Yes  
    No No  
    Missing .  
treated_malaria_12m Treated for malaria in the last 12 months (reported at enrolment)     String
    Yes Yes  
    No No  
    Missing .  
resid_b Residence at birth     String
    Village Village  
    Town/city Town/city
    Missing .  
resid_5y Residence between birth and 5 years     String
    Village Village  
    Town/city Town/city
    Missing .  
sm_screening_caa_pcr S. mansoni positive on either CAA or PCR at baseline     String
    Positive on at least one of CAA or PCR 1  
    Negative on both CAA and PCR 0  
sm_screening_pcr S. mansoni PCR result at baseline Positive, Negative   String
    Positive pos  
    Negative neg  
necator_pcr_screening Necator americanus PCR result baseline     String
    Positive Pos  
    Negative Neg  
    Missing .  
strongyloides_pcr_screening Strongyloides stercoralis PCR result at baseline     String
    Positive Pos  
    Negative Neg  
    Missing .