Data supporting "Does schistosome or malaria exposure contribute to urban-rural differences in vaccine responses in Uganda? A causal mediation analysis using data from three linked randomised controlled trials." – User Guide

Persistent identifier

10.17037/DATA.00003761

Description

This dataset comprises individual-level data from participants in the POPVAC series of three randomised controlled trials. POPVAC A was conducted among schoolchildren from Koome islands, Uganda (a schistosomiasis-endemic setting), POPVAC B was conducted among schoolchildren from Jinja district, Uganda (a malaria-endemic setting), POPVAC C was conducted among schoolchildren from Entebbe, Uganda (a lower infection prevalence setting).

Data collection methods

Collection procedures are outlined in "Does schistosome or malaria exposure contribute to urban-rural differences in vaccine responses in Uganda? A causal mediation analysis using data from three linked randomised controlled trials."

Geographic regions

Key dates

Population

School aged children

Ethics

Organisation Ethics ID Other information
MRC/UVRI and LSHTM Uganda Research Unit 16032 POPVAC A randomised controlled trial
MRC/UVRI and LSHTM Uganda Research Unit 16033 POPVAC B
MRC/UVRI and LSHTM Uganda Research Unit 16034 POPVAC C randomised controlled trial

Keywords

Vaccine responses, Schistosoma mansoni, Malaria, BCG, Population differences, Causal mediation analysis

Language of written material

English

Project information

Project name Funder/sponsor Grant number
POPVAC randomised controlled trial Medical Research Council MR/R02118X/1 and MC_PC_21034

Creators

Forename Surname Faculty / Dept Institution Role
Agnes Natukunda Faculty of Epidemiology and Population Health / Department of Infectious Disease Epidemiology and International Health London School of Hygiene & Tropical Medicine Data Creator
Gyaviira Nkurunungi   MRC/UVRI and LSHTM Uganda Research Unit Data Creator
Ludoviko Zirimenya Faculty of Infectious and Tropical Diseases / Department of Clinical Research London School of Hygiene & Tropical Medicine Data Creator
Jacent Nassuuna   MRC/UVRI and LSHTM Uganda Research Unit Data Creator
Alison M. Elliott Faculty of Epidemiology and Population Health / Department of Infectious Disease Epidemiology and International Health London School of Hygiene & Tropical Medicine Data Creator
Emily Webb Faculty of Infectious and Tropical Diseases / Department of Clinical Research London School of Hygiene & Tropical Medicine Data Creator

Associated roles

Forename Surname Faculty / Dept Institution Role
Christopher   Zziwa   London School of Hygiene & Tropical Medicine Researcher
Carol Ninsiima   MRC/UVRI and LSHTM Uganda Research Unit Researcher
Josephine Tumusiime   London School of Hygiene & Tropical Medicine Researcher
Ruth Nyanzi   London School of Hygiene & Tropical Medicine Researcher
Milly Namutebi   MRC/UVRI and LSHTM Uganda Research Unit Researcher
Fred Kiwudhu     Researcher
Govert van Dam   MRC/UVRI and LSHTM Uganda Research Unit Researcher
Paul Corstjens       Researcher
Robert Kizindo     Researcher
Ronald Nkangi     Researcher
Joyce Kabagenyi   London School of Hygiene & Tropical Medicine Researcher
Beatrice Nassanga   London School of Hygiene & Tropical Medicine Researcher
Stephen Cose   MRC/UVRI and LSHTM Uganda Research Unit Researcher
Anne Wajja   MRC/UVRI and LSHTM Uganda Research Unit Researcher
Pontiano Kaleebu   MRC/UVRI and LSHTM Uganda Research Unit Researcher

File description

Filename Description Access status Licence
POPVAC_settings_data Data from three POPVAC trials on vaccine responses Controlled – request access Data sharing agreement
POPVAC_settings_data_codebook POPVAC settings data dictionary Open access Creative Commons Attribution (CCBY)
3761_UserGuide User guide for POPVAC settings dataset Open access Creative Commons Attribution (CCBY)