Data supporting: "The effect of BCG revaccination on the response to unrelated vaccines in urban Ugandan adolescents: results of the POPVAC C randomised, controlled trial" – Data Codebook

Persistent identifier

10.17037/DATA.00003760

Description

This dataset comprises individual-level data from participants in the POPVAC C randomised controlled trial. POPVAC C was an open-label randomised controlled trial of Bacillus Calmette Guérin (BCG) revaccination versus no BCG among schoolchildren in Entebbe, Uganda (ISRCTN10482904). The aim of the trial was to comprehensively address the hypothesis that revaccination with BCG might enhance responses to unrelated vaccines. A portfolio of vaccines, of potential benefit to the children and comprising live, inert, oral and parenteral, was provided to enable a comprehensive assessment and comparison of effects of BCG revaccination on immune response to vaccines with different characteristics.

Data access statement

To access the data, requests must be made to the PI (Professor Alison Elliott). The request will be reviewed by the PI together with the POPVAC investigator team, in consultation with the POPVAC steering committee. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed.

Data codebook

The following variables are contained in the POPVAC C dataset.

Variable name Variable description Answer label Answer code Variable type
age Participant's age in years (age placed in categories where fewer participants)     Numeric
    Age 13-14 13-14  
    Age 15 15  
    Age 16 16  
    Age 17 17  
sex Participant's sex     String
    Female    
    Male    
yf_w4 Yellow fever vaccine administered at week 4     String
    Yes Yes  
    No No  
    Missing .  
hpv_w4 HPV vaccine administered at week 4     String
    Yes Yes  
    No No  
    Missing .  
ty1d1_w4 Oral typhoid dose 1 administered at week 4     String
    Yes Yes  
    No No  
    Missing .  
ty1d2_w4 Oral typhoid dose 2 administered at week 4     String
    Yes Yes  
    No No  
    Missing .  
ty1d3_w4 Oral typhoid dose 3 administered at week 4     String
    Yes Yes  
    No No  
    Missing .  
hpv_w8 HPV vaccine administered at week 8     String
    Yes Yes  
    No No  
    Missing .  
hpv_w28 HPV vaccine administered at week 28     String
    Yes Yes  
    No No  
    Missing .  
td_w28 Tetanus-diphtheria administered at week 28     String
    Yes Yes  
    No No  
    Missing .  
td_w52 Tetanus-diphtheria administered at week 52     String
    Yes Yes  
    No No  
    Missing .  
pzq_w8 Praziquantel administered at week 8     String
    Yes Yes  
    No No  
    Missing .  
pzq_w52 Praziquantel administered at week 52     String
    Yes Yes  
    No No  
    Missing .  
caa_pg_ml_wk0 S. mansoni CAA concentration at baseline, pg/ml Continuous   Numeric
caa_result_wk0 S. mansoni CAA result at baseline     String
    Positive Post  
    Negative Neg  
    Indecisive Indecisive  
necres_wk0 Necator americanus PCR result baseline     String
    Positive Post  
    Negative Neg  
    Missing .  
smres_wk0 S. mansoni PCR result at baseline     String
    Positive Post  
    Negative Neg  
    Missing .  
ssres_wk0 Strongyloides stercoralis PCR result at baseline     String
    Positive Post  
    Negative Neg  
    Missing .  
pfal_ct Plasmodium falciparum ct value at baseline     String
    NA Not applicable  
    Number    
pfal_res Plasmodium falciparum PCR result at baseline     String
    Positive Post  
    Negative Neg  
    Missing .  
tt_IgG_week8 Tetanus toxoid-specific IgG at week 28, IU/ml Continuous   Numeric
dt_IgG_week8 Diphtheria toxoid-specific IgG at week 28, IU/ml Continuous   Numeric
tt_IgG_week52 Tetanus toxoid-specific IgG at week 52, IU/ml Continuous   Numeric
dt_IgG_week52 Diphtheria toxoid-specific IgG at week 52, IU/ml Continuous   Numeric
bcg_week0 IFN-gamma response to BCG at week 0 (SFUs per million PBMCs) Continuous   Numeric
bcg_week8 IFN-gamma response to BCG at week 8 (SFUs per million PBMCs) Continuous   Numeric
bcg_week52 IFN-gamma response to BCG at week 52 (SFUs per million PBMCs) Continuous   Numeric
yfprnt_50_wk0 Yellow fever PRNT 50 titre at week 0 Continuous   Numeric
yfprnt_90_wk0 Yellow fever PRNT 90 titre at week 0 Continuous   Numeric
yfprnt_50_wk8 Yellow fever PRNT 50 titre at week 8 Continuous   Numeric
yfprnt_90_wk8 Yellow fever PRNT 90 titre at week 8 Continuous   Numeric
yfprnt_50_wk52 Yellow fever PRNT 50 titre at week 52 Continuous   Numeric
yfprnt_90_wk52 Yellow fever PRNT 90 titre at week 52 Continuous   Numeric
typhi_igg_wk0 S. typhi O:LPS-specific IgG at week 0, EU/ml Continuous   Numeric
typhi_igg_wk8 S. typhi O:LPS-specific IgG at week 8, EU/ml Continuous   Numeric
typhi_igg_wk52 S. typhi O:LPS-specific IgG at week 52, EU/ml Continuous   Numeric
hpv16_wk0 HPV-16-specific IgG concentration at week 0, EU/ml Continuous   Numeric
hpv18_wk0 HPV-18-specific IgG concentration at week 0, EU/ml Continuous   Numeric
hpv16_wk8 HPV-16-specific IgG concentration at week 8, EU/ml Continuous   Numeric
hpv18_wk8 HPV-18-specific IgG concentration at week 8, EU/ml Continuous   Numeric
hpv16_wk52 HPV-16-specific IgG concentration at week 52, EU/ml Continuous   Numeric
hpv18_wk52 HPV-18-specific IgG concentration at week 52, EU/ml Continuous   Numeric
trialarm Trial arm     String
    BCG (Bacillus Calmette Guérin) BCG  
    no BCG no BCG