10.17037/DATA.00003760
This dataset comprises individual-level data from participants in the POPVAC C randomised controlled trial. POPVAC C was an open-label randomised controlled trial of Bacillus Calmette Guérin (BCG) revaccination versus no BCG among schoolchildren in Entebbe, Uganda (ISRCTN10482904). The aim of the trial was to comprehensively address the hypothesis that revaccination with BCG might enhance responses to unrelated vaccines. A portfolio of vaccines, of potential benefit to the children and comprising live, inert, oral and parenteral, was provided to enable a comprehensive assessment and comparison of effects of BCG revaccination on immune response to vaccines with different characteristics.
To access the data, requests must be made to the PI (Professor Alison Elliott). The request will be reviewed by the PI together with the POPVAC investigator team, in consultation with the POPVAC steering committee. The request will be reviewed based on scientific value and to ensure there is no overlap with existing work. If the request is approved, before data is shared, ethics approval will need to be obtained in your host institution and a Data Transfer Agreement with the MRC/UVRI and LSHTM Uganda Research Unit must be completed.
The following variables are contained in the POPVAC C dataset.
Variable name | Variable description | Answer label | Answer code | Variable type |
age | Participant's age in years (age placed in categories where fewer participants) | Numeric | ||
Age 13-14 | 13-14 | |||
Age 15 | 15 | |||
Age 16 | 16 | |||
Age 17 | 17 | |||
sex | Participant's sex | String | ||
Female | ||||
Male | ||||
yf_w4 | Yellow fever vaccine administered at week 4 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
hpv_w4 | HPV vaccine administered at week 4 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
ty1d1_w4 | Oral typhoid dose 1 administered at week 4 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
ty1d2_w4 | Oral typhoid dose 2 administered at week 4 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
ty1d3_w4 | Oral typhoid dose 3 administered at week 4 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
hpv_w8 | HPV vaccine administered at week 8 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
hpv_w28 | HPV vaccine administered at week 28 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
td_w28 | Tetanus-diphtheria administered at week 28 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
td_w52 | Tetanus-diphtheria administered at week 52 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
pzq_w8 | Praziquantel administered at week 8 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
pzq_w52 | Praziquantel administered at week 52 | String | ||
Yes | Yes | |||
No | No | |||
Missing | . | |||
caa_pg_ml_wk0 | S. mansoni CAA concentration at baseline, pg/ml | Continuous | Numeric | |
caa_result_wk0 | S. mansoni CAA result at baseline | String | ||
Positive | Post | |||
Negative | Neg | |||
Indecisive | Indecisive | |||
necres_wk0 | Necator americanus PCR result baseline | String | ||
Positive | Post | |||
Negative | Neg | |||
Missing | . | |||
smres_wk0 | S. mansoni PCR result at baseline | String | ||
Positive | Post | |||
Negative | Neg | |||
Missing | . | |||
ssres_wk0 | Strongyloides stercoralis PCR result at baseline | String | ||
Positive | Post | |||
Negative | Neg | |||
Missing | . | |||
pfal_ct | Plasmodium falciparum ct value at baseline | String | ||
NA | Not applicable | |||
Number | ||||
pfal_res | Plasmodium falciparum PCR result at baseline | String | ||
Positive | Post | |||
Negative | Neg | |||
Missing | . | |||
tt_IgG_week8 | Tetanus toxoid-specific IgG at week 28, IU/ml | Continuous | Numeric | |
dt_IgG_week8 | Diphtheria toxoid-specific IgG at week 28, IU/ml | Continuous | Numeric | |
tt_IgG_week52 | Tetanus toxoid-specific IgG at week 52, IU/ml | Continuous | Numeric | |
dt_IgG_week52 | Diphtheria toxoid-specific IgG at week 52, IU/ml | Continuous | Numeric | |
bcg_week0 | IFN-gamma response to BCG at week 0 (SFUs per million PBMCs) | Continuous | Numeric | |
bcg_week8 | IFN-gamma response to BCG at week 8 (SFUs per million PBMCs) | Continuous | Numeric | |
bcg_week52 | IFN-gamma response to BCG at week 52 (SFUs per million PBMCs) | Continuous | Numeric | |
yfprnt_50_wk0 | Yellow fever PRNT 50 titre at week 0 | Continuous | Numeric | |
yfprnt_90_wk0 | Yellow fever PRNT 90 titre at week 0 | Continuous | Numeric | |
yfprnt_50_wk8 | Yellow fever PRNT 50 titre at week 8 | Continuous | Numeric | |
yfprnt_90_wk8 | Yellow fever PRNT 90 titre at week 8 | Continuous | Numeric | |
yfprnt_50_wk52 | Yellow fever PRNT 50 titre at week 52 | Continuous | Numeric | |
yfprnt_90_wk52 | Yellow fever PRNT 90 titre at week 52 | Continuous | Numeric | |
typhi_igg_wk0 | S. typhi O:LPS-specific IgG at week 0, EU/ml | Continuous | Numeric | |
typhi_igg_wk8 | S. typhi O:LPS-specific IgG at week 8, EU/ml | Continuous | Numeric | |
typhi_igg_wk52 | S. typhi O:LPS-specific IgG at week 52, EU/ml | Continuous | Numeric | |
hpv16_wk0 | HPV-16-specific IgG concentration at week 0, EU/ml | Continuous | Numeric | |
hpv18_wk0 | HPV-18-specific IgG concentration at week 0, EU/ml | Continuous | Numeric | |
hpv16_wk8 | HPV-16-specific IgG concentration at week 8, EU/ml | Continuous | Numeric | |
hpv18_wk8 | HPV-18-specific IgG concentration at week 8, EU/ml | Continuous | Numeric | |
hpv16_wk52 | HPV-16-specific IgG concentration at week 52, EU/ml | Continuous | Numeric | |
hpv18_wk52 | HPV-18-specific IgG concentration at week 52, EU/ml | Continuous | Numeric | |
trialarm | Trial arm | String | ||
BCG (Bacillus Calmette Guérin) | BCG | |||
no BCG | no BCG |