10.17037/DATA.00003373
This dataset and accompanying R code contains the data and analysis that was used to produce the results reported in the manuscript "Prevalence of subclinical pulmonary tuberculosis and its association with HIV in household contacts of tuberculosis in two South African provinces: analysis of a cluster-randomised trial".
Applications for the dataset will be reviewed by Professor Emily Webb (Emily.Webb@lshtm.ac.uk) and Professor Neil Martinson (info@phru.co.za), in conjunction with the University of the Witwatersrand Institutional Review Board.
Applicants are requested to provide the following information when applying for access:
Applications will be assessed on the basis of the following criteria:
The “TBdataset.Rdata” contains the following variables.
Variable name | Variable label | Codes |
hhid | Household ID | |
study_id | Study ID | |
study_site | Study Site | |
hhmembers | Number of household members | |
i_sex | Index patient sex | |
i_age | Index patient age (years) | |
i_agp | Index patient age group | |
i_hiv | Index patient HIV status | |
i_art | Index patient taking anti-retroviral therapy or not (if HIV positive) | |
h_sex | Household contact sex | |
h_age | Household contact age | |
h_smk | Household contact smoking status | |
h_alc | Household contact drinks alcohol or not | |
h_hiv | Household contact HIV status | |
h_art | Household contact taking anti-retroviral therapy or not (if HIV positive) | |
h_cgh | Household contact history of cough (number of days or 0 if not present) | |
h_spt | Household contact history of sputum (number of days or 0 if not present) | |
h_hpt | Household contact history of haemoptysis (number of days or 0 if not present) | |
h_lwt | Household contact history of weight loss (number of days or 0 if not present) | |
h_nsw | Household contact history of night sweats (number of days or 0 if not present) | |
h_fev | Household contact history of fever (number of days or 0 if not present) | |
h_xpt | Household contact sputum Xpert nucleic acid amplification test (NAAT) result | |
h_smr | Household contact sputum smear for TB microscopy result | |
h_cul | Household contact sputum culture for TB result | |
h_mtb | History of TB | 1=yes 0=no |
employment | Household contact employment status | |
cd4 | Household contact CD4 count | |
cd4_date | Date of CD4 count | |
h_dm | Household contact history of diabetes | |
h_agegrp | Household contact age group | |
cd4_cat | CD4 count categorical groupings | |
cum_symp | h_cgh+h_lwt+h_nsw+h_fev | |
Symptomatic | At least one of cough, fever, weight loss or night sweats (any duration) = symptomatic | |
scTB | Household contact categorised as subclinical TB | 1=yes 0=no |
activeTB | Household contact categorised as active TB | 1=yes 0=no |
microTB_status | Microbiological TB status | |
cgh_binary | Household contact presence of cough (any duration) | |
spt_binary | Household contact presence of sputum (any duration) | |
hpt_binary | Household contact presence of haemoptysis (any duration) | |
lwt_binary | Household contact presence of weight loss (any duration) | |
nsw_binary | Household contact presence of night sweats (any duration) | |
fev_binary | Household contact presence of fever (any duration) | |
binaryHIV | Household contact HIV-positive status | 1=yes 0=no |