Data supporting "Prevalence of subclinical pulmonary tuberculosis and its association with HIV in household contacts of tuberculosis in two South African provinces: analysis of a cluster-randomised trial" – Data codebook

Permanent identifier

10.17037/DATA.00003373

Description

This dataset and accompanying R code contains the data and analysis that was used to produce the results reported in the manuscript "Prevalence of subclinical pulmonary tuberculosis and its association with HIV in household contacts of tuberculosis in two South African provinces: analysis of a cluster-randomised trial".

Data access procedure

Applications for the dataset will be reviewed by Professor Emily Webb (Emily.Webb@lshtm.ac.uk) and Professor Neil Martinson (info@phru.co.za), in conjunction with the University of the Witwatersrand Institutional Review Board.

Applicants are requested to provide the following information when applying for access:

Applications will be assessed on the basis of the following criteria:

  1. The proposed analysis is compatible with the consent agreement that the study participant signed.
  2. The proposed analysis can be performed using the fully de-identified dataset.
  3. The applicant is able to complete and comply with a Data Transfer Agreement (DTA), which outlines conditions of storage and use.

Data codebook

The “TBdataset.Rdata” contains the following variables.

Variable name Variable label Codes
hhid Household ID  
study_id Study ID  
study_site Study Site  
hhmembers Number of household members  
i_sex Index patient sex  
i_age Index patient age (years)  
i_agp Index patient age group  
i_hiv Index patient HIV status  
i_art Index patient taking anti-retroviral therapy or not (if HIV positive)  
h_sex Household contact sex  
h_age Household contact age  
h_smk Household contact smoking status  
h_alc Household contact drinks alcohol or not  
h_hiv Household contact HIV status  
h_art Household contact taking anti-retroviral therapy or not (if HIV positive)  
h_cgh Household contact history of cough (number of days or 0 if not present)  
h_spt Household contact history of sputum (number of days or 0 if not present)  
h_hpt Household contact history of haemoptysis (number of days or 0 if not present)  
h_lwt Household contact history of weight loss (number of days or 0 if not present)  
h_nsw Household contact history of night sweats (number of days or 0 if not present)  
h_fev Household contact history of fever (number of days or 0 if not present)  
h_xpt Household contact sputum Xpert nucleic acid amplification test (NAAT) result  
h_smr Household contact sputum smear for TB microscopy result  
h_cul Household contact sputum culture for TB result  
h_mtb History of TB 1=yes 0=no
employment Household contact employment status  
cd4 Household contact CD4 count  
cd4_date Date of CD4 count  
h_dm Household contact history of diabetes  
h_agegrp Household contact age group  
cd4_cat CD4 count categorical groupings  
cum_symp h_cgh+h_lwt+h_nsw+h_fev  
Symptomatic At least one of cough, fever, weight loss or night sweats (any duration) = symptomatic  
scTB Household contact categorised as subclinical TB 1=yes 0=no
activeTB Household contact categorised as active TB 1=yes 0=no
microTB_status Microbiological TB status  
cgh_binary Household contact presence of cough (any duration)  
spt_binary Household contact presence of sputum (any duration)  
hpt_binary Household contact presence of haemoptysis (any duration)  
lwt_binary Household contact presence of weight loss (any duration)  
nsw_binary Household contact presence of night sweats (any duration)  
fev_binary Household contact presence of fever (any duration)  
binaryHIV Household contact HIV-positive status 1=yes 0=no