https://doi.org/10.17037/DATA.00002656
Kerac, M, Anujuo, K, Thompson, D, McKenzie, K, Badaloo, A, Boyne, M, Forrester, T, Gluckman, P, Hanson, M, Byrne, C, Cutfield, W, Kanjala, C and Opondo, C
LION is an existing prospective cohort of survivors of severe malnutrition in Jamaica which has been followed-up post-discharge after been identified as severely malnourished and treated with specialised feeds. The cohort consist of malnourished children treated in inpatient care (1965-93). Included in the study are children with severe wasting (weight-for-age < 60%) or oedematous malnutrition (weight-for-age 60-80%, plus oedema).
Data from a cross-sectional retrospective survey on non-communicable disease (NCD) risk in adult survivors of severe malnutrition in childhood carried out between 2008-2012 at the Tropical Metabolism Research Unit (TMRU), the University of the West Indies (UWI), Jamaica. Adult data include blood pressure, anthropometric measures, body composition data, laboratory test results, and self-reported data relating to medical history, drug history and socioeconomic status. Childhood data include birth weight, and weight, length (height) and mid upper arm circumference (MUAC) measurements taken on admission, during hospitalization and up to 2 years post discharge from hospital.
Interviews with adult survivors were conducted face-to-face by trained research nurses when the participants reported to the TMRU. Additional data came from anthropometry, blood pressure and body composition measurements as well as lab test results. In addition, data relating to childhood hospitalization for severe malnutrition were abstracted from the medical records of the participants.
This dataset is not held in the LSHTM repository. Data management and access arrangements for this dataset are handled by researchers located at the University of the West Indies (UWI), in accordance with the study ethics approvals.
Please read the data codebook and make a note of variables that you wish to request prior to applying for access. Access requests submitted through the LSHTM repository will be sent to the LSHTM project team and passed onto the UWI researchers collaborators.
The following data table has been provided for the ‘LION_SM_NCD’ dataset. However, as noted above, the dataset has not been deposited to the LSHTM repository and staff are unable to verify its completeness or accuracy. Please refer all questions to the study team.
| Variable name | Description | Value codes | Stata data type |
| ID | participant project ID | float | |
| SEX | sex of participants |
1=male 2=female |
byte |
| Birthweight | birthweight, kg | float | |
| Ad_weight | admission weight, kg | float | |
| Ad_height | admission height, cm | float | |
| Ad_WAZ | admission WAZ | float | |
| Ad_HAZ | admission HAZ | float | |
| Ad_WHZ | admission WHZ | float | |
| Ad_MUAC | admission MUAC, cm | float | |
| Diagnosis | diagnosis for SAM |
1=kwashiorkor 2=marasmus 3=kwash/maras 4=undernourished |
byte |
| MinW_weight | weight at minimum weight, kg | float | |
| MinW_height | height at minimum weight, cm | float | |
| MinW_WAZ | minimum weight WAZ | float | |
| MinW_HAZ | minimum weight HAZ | float | |
| MinW_WHZ | minimum weight WHZ | float | |
| MinW_MUAC | minimum weight MUAC, cm | float | |
| MaxW_weight | weight at maximum weight, kg | float | |
| MaxW_height | height at maximum weight, cm | float | |
| MaxW_WAZ | maximum weight WAZ | float | |
| MaxW_HAZ | maximum weight HAZ | float | |
| MaxW_WHZ | maximum weight WHZ | float | |
| MaxW_MUAC | maximum weight MUAC, cm | float | |
| Disch_weight | weight at discharge from care, kg | float | |
| Disch_height | height at discharge from care, cm | float | |
| Disch_WAZ | discharge from care WAZ | float | |
| Disch_HAZ | discharge from care HAZ | float | |
| Disch_WHZ | discharge from care WHZ | float | |
| Disch_MUAC | discharge from care MUAC, cm | float | |
| FUP1_weight | weight at follow-up 1, kg (paediatic) | float | |
| FUP1_height | height at follow-up 1, cm (paediatic) | float | |
| FUP1_WAZ | WAZ at follow-up 1 (paediatic) | float | |
| FUP1_HAZ | HAZ at follow-up 1 (paediatic) | float | |
| FUP1_WHZ | WHZ at follow-up 1 (paediatic) | float | |
| FUP1_MUAC | MUAC at follow-up 1, cm (paediatic) | float | |
| Fat_percent_DXA | fat percent, DEXA (adult, follow-up 2) | float | |
| Fat_grams_DXA | fat mass in grams, DEXA (adult, follow-up 2) | long | |
| Lean_grams_DXA | lean mass in grams, DEXA (adult, follow-up 2) | long | |
| BLMI_DXA | Body lean mass index kg/m2, DEXA | float | |
| BFMI_DXA | Body fat mass index kg/m2, DEXA | float | |
| AndroidFat_percent_DXA | android fat percent, DEXA (adult) | float | |
| AndroidFat_grams_DXA | android fat mass in grams, DEXA | int | |
| Fat_kg_DXA | fat mass in kg, DEXA | float | |
| Lean_kg_DXA | lean mass in kg, DEXA | float | |
| AndroidFat_kg_DXA | android fat mass in kg, DEXA | float | |
| SystolicBP | systolic blood pressure, mmHg (adult) | float | |
| DiastolicBP | diastolic blood pressure, mmHg (adult) | float | |
| FBG | Fasting serum glucose, mmol/L (adult) | float | |
| FSI | Fasting serum insulin, uIU/mL | float | |
| FUP2_weight | weight at follow-up 2, kg (adult) | float | |
| FUP2_height | height at follow-up 2, cm (adult) | float | |
| BMI | Body mass index kg/m2 (adult) | float | |
| FUP2_age_years | age at follow-up 2 (adult) | float | |
| Waist_hip_ratio | waist hip ratio, w/h , cm (adult) | float | |
| Resistance | BIA resistance ohm (adult) | float | |
| Reactance | BIA reactance ohm (adult) | float | |
| Impedance | BIA impedance ohm (adult) | float | |
| DOB1 | date of birth | float | |
| admission_date1 | admission date | float | |
| MinW_date1 | date of minimum weight | float | |
| MaxW_date1 | date of maximum weight | float | |
| Discharge_date1 | date of discharge from care | float | |
| FUP1_date1 | date of follow-up 1 (1 year post discharge) | float | |
| FUP2_date1 | date of follow-up 2 (adult) | float | |
| age_months_Ad | age in months at admission | float | |
| age_years_Ad | age in years at admission | float | |
| age_days_Ad | age in days at admission | float | |
| age_months_MinW | age in months at minimum weight | float | |
| age_years_MinW | age in years at minimum weight | float | |
| age_months_MaxW | age in months at maximum weight | float | |
| age_years_MaxW | age in years at maximum weight | float | |
| age_months_Disch | age in months at discharge | float | |
| age_years_Disch | age in years at dischrge | float | |
| age_months_FUP1 | age in months at follow-up 1 | float | |
| age_years_FUP1 | age in years at follow-up 1 (1yrPD) | float | |
| age_years_FUP2 | age in years at follow-up 2 (adult) | float | |
| days_Disch_MinW | days between minimum weight and discharge | float | |
| days_MaxW_MinW | days between minimum weight and maximum weight | float | |
| months_FUP1_Disch | months between discharge and follow-up 1 | float | |
| days_FUP1_Disch | days between discharge and follow-up 1 | float | |
| years_FUP2_Disch | years between discharge and follow-up 1 | float | |
| dWAZ_MaxWMinW | delta WAZ from min. weight to max. weight | float | |
| dWAZ_d_MaxWMinW | PMGr1-delta WAZ/day from min. weight to max. weight | float | |
| dWAZ_d_MaxWMinW_quintile | PMGr1-5 quantiles of dWAZ_d_MaxWMinW | byte | |
| grams_d_MaxWMinW | PMGr3-delta grams/day from min. weight to max. weight | float | |
| grams_d_MaxWMinW_quintile | PMGr3-5 quantiles of grams_d_MaxWMinW | byte | |
| dWAZ_MinWdisch | delta WAZ from min. weight to discharge | float | |
| dWAZ_d_MinWdisch | delta WAZ/day from min. weight to max. weight | float | |
| dWAZ_d_MinWdisch_quintile | 5 quantiles of dWAZ_d_MinWdisch | byte | |
| grams_d_MinWdisch | grams/day from min. weight to discharge | float | |
| grams_d_MinWdisch_quintile | 5 quantiles of grams_d_MinWdisch | byte | |
| grams_kg_d_MinWdisch | grams/kg/day from min. weight to discharge | float | |
| grams_kg_d_MinWdisch_quintile | 5 quantiles of grams_kg_d_MinWdisch | byte | |
| dWAZ_m_dischFUP1 | PMGr4-delta WAZ/month from min.weight tofollow-up 1 | float | |
| dWAZ_m_dischFUP1_quintile | PMGr4-5 quantiles of dWAZ_m_dischFUP1 | byte | |
| grams_d_dischFUP1 | grams/day from discharge to follow-up 1 | float | |
| grams_d_dischFUP1_quintile | 5 quantiles of grams_d_dischFUP1 | byte | |
| dHAZ_m_dischFUP1 | PMGr6-delta HAZ/month from discharge to follow-up 1 | float | |
| dHAZ_m_dischFUP1_quintile | PMGr6-5 quantiles of dHAZ_m_dischFUP1 | byte | |
| FFMI | BIA fat free mass index, 1/z (adult) | float | |
| FFMI_10K | BIA fat free mass index (x10000) | float | |
| pred_FFMI | Fitted values of BMI regressed on 1/z | float | |
| resid_FFMI | Residuals of BMI regressed on 1/z | float | |
| FMI_r1 | resid_FFMI X 10000=proxy for fat mass index | float | |
| FMI_10 | BIA fat mass index (+10), | float | |
| dWAZ_d_MaxWMinW_q | PMGr1-mean 5 quantiles of dWAZ_d_MaxWMinW_quintile, PMGrA | float | |
| grams_d_MaxWMinW_q | PMGr3-mean 5 quantiles of grams_d_MaxWMinW_quintile, PMGrB | float | |
| dWAZ_d_MinWdisch_q | 5 quantiles of dWAZ_d_MinWdisch_quintile | float | |
| dWAZ_m_dischFUP1_q | PMGr4-5 quantiles of dWAZ_m_dischFUP1_quintile | float | |
| dHAZ_m_dischFUP1_q | PMGr6-5 quantiles of dHAZ_m_dischFUP1_quintile | float | |
| mweight_MaxWMinW | mean weight of maximum weight and minimum weight | float | |
| grams_kg_d_MaxWMinW2 | PMGr2_g/kg/day between maxW and minW | float | |
| grams_kg_d_MaxWMinW2_quintile | PMGr2_5 quantiles of grams_kg_d_MaxWMinW2 | byte | |
| grams_kg_d_MaxWMinW2_q | PMGr2_mean5 quantiles of grams_kg_d_MaxWMinW2_quintile | float | |
| mweight_dischFUP1 | mean weight of discharge and FUP1 weights | float | |
| grams_kg_d_dischFUP12 | g/kg/day discharge, FUP1 mean weight | float | |
| grams_kg_d_dischFUP12_quintile | 5 quantiles of grams_kg_d_dischFUP12 | byte | |
| grams_kg_d_dischFUP12_q | mean5 quantiles of grams_kg_d_dischFUP12_quintile | float | |
| days_Ad_Disch | days between admission and discharge | float | |
| days_Ad_FUP1 | days between admission and follow-up 1 | float | |
| years_Ad_FUP2 | years between admission and follow-up 2 | float | |
| dgrams_dischFUP13 | change in grams from discharge to follow-up 1 | float | |
| grams_kg_m_dischFUP13 | PMGr5-change in grams/kg/month between discharge and follow-up 1 | float | |
| grams_kg_m_dischFUP13_quintile | PMGr5-5 quantiles of grams_kg_m_dischFUP13 | byte | |
| grams_kg_m_dischFUP13_q | PMGr5-5 quantiles of grams_kg_m_dischFUP13_quintile | float | |
| tot_cholest | total cholesterol | float | |
| triglyceride | triglycerides | float | |
| hdl | HDL- high density lipoprotein | float | |
| ldl | LDL- low density lipoprotein | float | |
| alanine_trans | alanine transaminase | int | |
| adiponectin | adiponectin | float | |
| AG_ratio | android/ gynoid ratio | float | |
| HOMA | HOMA insulin resistance | float |
Post-malnutrition growth, Childhood, Non-communicable diseases (NCD), Anthropometry, Malnutrition, Severe acute malnutrition, Growth condition, Rehabilitation, Diabetes, Hypertension, Obesity, Risk factors, Long-term outcome
1 January 1963 - 31 December 1993
| Project name | Funder | Funder grant number |
| CHild Malnutrion & Adult NCD: Generatign Evidence on Mechanistic Links to Inform Policy/Practice (CHANGE Study) | Medical Research Council | MR/V000802/1 |