https://doi.org/10.17037/DATA.00002372
Data collected as part of the “High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis” (RIFT) study, a phase 2 open-label randomized trial (ISRCTN42218549). It contains information obtained from 36 patients who were diagnosed with TB meningitis and enrolled between January 14 and December 17, 2019 at Kiruddu National Referral Hospital in Kampala, Uganda. Variables include baseline clinical and laboratory results, as well as clinical statuses, functional statuses, results of depression screening, and detailed neurocognitive assessment of across motor and cognitive domains at 8 and 24 weeks of follow up. Results of neurocognitive tests are reported both as raw scores and as Z-scores standardized to a cohort of HIV-negative Ugandan age- and education-matched controls.
Kiruddu National Referral Hospital in Kampala, Uganda
Data collected between January 14 and December 17, 2019
36 patients who were diagnosed with TB meningitis and enrolled between January 14 and December 17, 2019 at Kiruddu National Referral Hospital in Kampala, Uganda
Ethics approval information provided in https://doi.org/10.1186/ISRCTN42218549.
| Organisation | Ethics ID | Other information |
| Mulago Hospital Research Ethics Committee | MHREC 1260 | Approved 01 March 2018 |
| London School of Hygiene & Tropical Medicine Research Ethics Committee | 14388 | Approved 11 Dec 2017 |
Tuberculous meningitis, HIV, Neurocognitive, Depression, Uganda
English
The High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis: a phase II open-label randomised controlled trial (the RifT study) was funded by Wellcome Trust and Medical Research Council. Trial registration: ISRCTN42218549.
| Forename | Surname | Faculty / Dept | Institution | Role |
| Fiona | Cresswell | Faculty of Infectious and Tropical Diseases / Dept of Clinical Research | London School of Hygiene & Tropical Medicine | Data Creator |
| Carson | Quinn | Data Creator |
| Variable | Description | Answer code | Answer label |
| ID | De-identified patient number | ||
| ed_cat | Education category | ||
| 1 | <7 years | ||
| 2 | 7 to 12 years | ||
| 3 | >12 years | ||
| age | Age (5 year categories) | ||
| sex | |||
| 1 | Male | ||
| 2 | Female | ||
| gcs_000 | Glascow Coma Score at presentation | ||
| cd4_000 | CD4 Tcell count at presentation cells/µL | ||
| csf_wbc_000 | cerebrospinal fluid (CSF) leukocyte count at initial lumbar puncture (cells/µL) | ||
| csf_protein_000 | CSF protein concentration at initial lumbar puncture (mg/dL) | ||
| csf_glucose_mg_000 | CSF glucose concentration at initial lumbar puncture (mg/dL) | ||
| mrc_000 | British medical research council TBM severity grade | ||
| micro_TBM | Microbiologically-confirmed TBM. | ||
| 1 | Confirmed | ||
| 0 | not confirmed | ||
| sodium_000 | Plasma Sodium at presentation (mEq/L) | ||
| 1 | taking antiretroviral therapy at presentation | ||
| 2 | not taking antiretroviral therapy at presentation | ||
| on_art_000 | |||
| r_arm | Trial arm | ||
| 1 | High dose IV rifampin | ||
| 2 | High dose oral rifampin | ||
| 3 | Standard of care | ||
| clinicalstatus_080 | Clinical status at 8 weeks | ||
| 1 | Alive | ||
| 2 | Dead | ||
| mrs_080 | Modified Rankin Scale score at 8 weeks | ||
| karnofskyscore_080 | Karnofsky performance score at 8 weeks | ||
| phq9_080 | Patient Health Questionaire-9 score at 8 weeks | ||
| avlt_total_080 | Auditory Verbal Learning Test total score (raw) at 8 weeks | ||
| avlt_recall_080 | Auditory Verbal Learning Test - recall, total score (raw) at 8 weeks | ||
| digit_forward_080 | Digit Span Forward result (raw) at 8 weeks | ||
| digit_backward_080 | Digit Span Backward result (raw) at 8 weeks | ||
| sdm_080 | Symbol Digit Modality score (raw) at 8 weeks | ||
| gpb_avg_080 | Grooved Pegboard average of both hands score (raw) at 8 weeks | ||
| ftd_avg_080 | Finger Tapping score (raw) at 8 weeks | ||
| vf_correct_080 | Semantic Verbal Fluency score (raw) at 8 weeks | ||
| tgait_avg_080 | Timed gait average of 3 trials (raw) at 8 weeks | ||
| ct1_time_080 | Color Trails 1 score (raw) at 8 weeks | ||
| ct2_time_080 | Color Trails 2 score (raw) at 8 weeks | ||
| avlt_z_080 | Auditory Verbal Learning Test total score (Z-score) at 8 weeks | ||
| avltrecall_z_080 | Auditory Verbal Learning Test - recall, total score (Z-score) at 8 weeks | ||
| dsf_z_080 | Digit Span Forward result (Z-score) at 8 weeks | ||
| dsb_z_080 | Digit Span Backward result (Z-score) at 8 weeks | ||
| sdm_z_080 | Symbol Digit Modality score (Z-score) at 8 weeks | ||
| gpb_z_avg_080 | Grooved Pegboard average of both hands score (Z-score) at 8 weeks | ||
| ftd_z_080 | Finger Tapping score (Z-score) at 8 weeks | ||
| vf_z_080 | Semantic Verbal Fluency score (Z-score) at 8 weeks | ||
| tgait_z_080 | Timed gait average of 3 trials (Z-score) at 8 weeks | ||
| ct1_z_080 | Color Trails 1 score (Z-score) at 8 weeks | ||
| ct2_z_080 | Color Trails 2 score (Z-score) at 8 weeks | ||
| qnpz8_080 | Quantitative Neurocognitive Performance Z-score at 8 weeks | ||
| clinicalstatus_240 | Clinical status at 24 weeks | ||
| 1 | Alive | ||
| 2 | Dead | ||
| mrs_240nd | Modified Rankin Scale score at 24 weeks | ||
| karnofskyscore_240 | Karnofsky performance score at 24 weeks | ||
| phq9_240 | Patient Health Questionaire-9 score at 24 weeks | ||
| avlt_total_240 | Auditory Verbal Learning Test total score (raw) at 24 weeks | ||
| avlt_recall_240 | Auditory Verbal Learning Test - recall, total score (raw) at 24 weeks | ||
| digit_forward_240 | Digit Span Forward result (raw) at 24 weeks | ||
| digit_backward_240 | Digit Span Backward result (raw) at 24 weeks | ||
| sdm_240 | Symbol Digit Modality score (raw) at 24 weeks | ||
| gpb_avg_240 | Grooved Pegboard average of both hands score (raw) at 24 weeks | ||
| ftd_avg_240 | Finger Tapping score (raw) at 24 weeks | ||
| vf_correct_240 | Semantic Verbal Fluency score (raw) at 24 weeks | ||
| tgait_avg_240 | Timed gait average of 3 trials (raw) at 24 weeks | ||
| ct1_time_240 | Color Trails 1 score (raw) at 24 weeks | ||
| ct2_time_240 | Color Trails 2 score (raw) at 24 weeks | ||
| avlt_z_240 | Auditory Verbal Learning Test total score (Z-score) at 24 weeks | ||
| avltrecall_z_240 | Auditory Verbal Learning Test - recall, total score (Z-score) at 24 weeks | ||
| dsf_z_240 | Digit Span Forward result (Z-score) at 24 weeks | ||
| dsb_z_240 | Digit Span Backward result (Z-score) at 24 weeks | ||
| sdm_z_240 | Symbol Digit Modality score (Z-score) at 24 weeks | ||
| gpb_z_avg_240 | Grooved Pegboard average of both hands score (Z-score) at 24 weeks | ||
| ftd_z_240 | Finger Tapping score (Z-score) at 24 weeks | ||
| vf_z_240 | Semantic Verbal Fluency score (Z-score) at 24 weeks | ||
| tgait_z_240 | Timed gait average of 3 trials (Z-score) at 24 weeks | ||
| ct1_z_240 | Color Trails 1 score (Z-score) at 24 weeks | ||
| ct2_z_240 | Color Trails 2 score (Z-score) at 24 weeks | ||
| qnpz8_240 | Quantitative Neurocognitive Performance Z-score at 24 weeks | ||