Prevalence of TB Prevalence of positive LAM Sensitivity Specificity PPV NPV Gold standard = confirmed* and clinical† TB n/N % n/N % n/N % (95% CI) n/N % (95% CI) n/N % (95% CI) n/N % (95% CI) Grade 1‡ cut-off 56/424 13.2% 24/424 5.7% 8/56 "14.3% (6.4, 26.2)" 352/368 "95.7% (93.0, 97.5)" 8/24 "33.3% (15.6, 55.3)" 352/400 "88.0% (84.4, 91.0)" CD4 <100 35/187 18.7% 12/187 6.4% 6/35 "17.1% (6.6, 33.6)" 146/152 "96.1% (91.6, 98.5)" 6/12 "50.0% (21.1, 78.9)" 146/175 "83.4% (77.1, 88.6)" CD4 ?100 21/237 8.9% 12/237 5.1% 2/21 "9.5% (1.2, 30.4)" 206/216 "95.4% (91.7, 97.8)" 2/12 "16.7% (2.1, 48.4)" 206/225 "91.6% (87.1, 94.8)" Grade 2§ cut-off 56/424 13.2% 8/424 1.9% 3/56 "5.4% (1.1, 14.9)" 363/368 "98.6% (96.9, 99.6)" 3/8 "37.5% (8.5, 75.5)" 363/416 "87.3% (83.7, 90.3)" Gold standard = confirmed* TB (all clinical†TB excluded) (N = 408) Grade 1‡ cut-off 40/408 9.8% 21/408 5.1% 5/40 "12.5% (4.2, 26.8)" 352/368 "95.7% (93.0, 97.5)" 5/21 "23.8% (8.2, 47.2)" 352/387 "91.0% (87.6, 93.6)" CD4 <100 24/176 13.6% 10/176 5.7% 4/24 "16.7% (4.7, 37.4)" 146/152 "96.1% (91.6, 98.5)" 4/10 "40.0% (12.2, 73.8)" 146/166 "88.0% (82.0, 92.5)" CD4 ?100 16/232 6.9% 11/232 4.7% 1/16 "6.3% (0.2, 30.2)" 206/216 "95.4% (91.7, 97.8)" 1/11 "9.1% (0.2, 41.3)" 206/221 "93.2% (89.1, 96.2)" Grade 2§ cut-off 40/408 9.8% 8/408 2.0% 3/40 "7.5% (1.6, 20.4)" 363/368 "98.6% (96.9, 99.6)" 3/8 "37.5% (8.5, 75.5)" 363/400 "90.8% (87.5, 93.4)"