Data for: "Association between Female Genital Schistosomiasis and HIV-1 incidence: a retrospective cohort study"

Permanent identifier

https://doi.org/10.17037/DATA.00001927

Description

The longitudinal follow-up of women in the HPTN 071 (PopART) trial in two schistosomiasis-endemic communities in Zambia provided an opportunity for a nested study of the association of Female Genital Schistosomiasis (FGS) with HIV-1 incidence. In the bilharzia and HIV (BILHIV) study, we conducted an array of diagnostic tests for S. haematobium infection and FGS, demonstrating that self-collected genital swabs had comparable sensitivity to clinic-based, midwife-collected CVL for the detection of Schistosoma DNA by real-time PCR. HIV-1 outcomes were available for the HPTN 071 (PopART) Population Cohort at final follow-up. BILHIV study participants were consecutively recruited from the Population Cohort, providing the opportunity to compare the rate of incident HIV-1 infection in women with and without FGS, with power ultimately determined by the number of HIV seroconversion events in this nested study.

Data collection methods

The home visit included assessment of eligibility, a questionnaire, genital self-sampling (cervical and vaginal), and a single urine specimen. Questionnaire data were captured on tablets using Open Data Kit.

Data analysis and preparation

Please consult “Cervicovaginal Immune Activation in Zambian Women With Female Genital Schistosomiasis” (10.3389/fimmu.2021.620657), published in Frontiers in immunology.

Key dates

Data collection took place between 8 January 2018 and 31 August 2020.

Population

Women diagnosed with female genital schistosomiasis in Zambia.

Privacy

Names and other direct identifiers have been removed prior to submission. Participant age and other information that may be used to identify participants in combination with other data has been placed into broad categories to reduce the disclosure risk. However, there remain a number of unique measurements. These values will be processed when preparing data for access.

Data may only be shared for use in health research, where ethical approval for the work has been obtained.

Ethics

The cross-sectional bilharzia and HIV (BILHIV) study was nested in HPTN 071 (PopART), a cluster randomized trial to measure the impact of an HIV-1 combination prevention package. The same ethics approvals apply.

Keywords

Female Genital Schistosomiasis, HIV, Incidence

Language of written material

English

Project information

Creators

Associated roles

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