https://doi.org/10.17037/DATA.00001695
Statins are one of the most commonly prescribed drugs in the United Kingdom. There is strong evidence that they are effective in safely reducing heart disease. However, there is some doubt about whether statins cause muscle pain, stiffness or weakness. The StatinWISE study sought to understand the effect of statins on muscle symptoms. The study recruited 200 volunteers from across England and Wales who had either recently stopped taking statins due to muscle symptoms, or were considering stopping due to muscle symptoms.
This collection contains four datasets that contain demographic, patient flow, primary VAS and secondary questionnaire data, as well as a STATA Do script that may be used to recruit the analysis. These datasets are made available via controlled access, subject to applicants providing proof of ethical approval for their proposed research.
Outlined in the protocol and publications linked to this data record.
Human population
Personal identifiers have been removed from the dataset.
Statins, Cardiovascular disease, Medication side effects
English
| Organisation | Ethics ID | Other information |
| London School of Hygiene & Tropical Medicine, London, United Kingdom | IRAS: 197990; REC: 16/SC/0324; LSHTM: 11758 | |
| ClinicalTrials.gov | NCT02781064 | https://clinicaltrials.gov/ct2/show/NCT02781064 |
| Project name | Funder/sponsor | Grant number |
| STATIN: Web-based Investigation of Side Effects (STATINWISE) / A Series of Randomised Controlled N-of 1 Trials in Patients Who Have Discontinued or Are Considering Discontinuing Statin Use Due to Muscle-related Symptoms to Assess if Atorvastatin Treatment Causes More Muscle Symptoms Than Placebo | National Institute for Health Research (NIHR) Health Technology Assessment | 14/49/159 |
Use of data generated by the StatinWISE study requires proof of ethical approval for the proposed research.
| Forename | Surname | Faculty / Dept | Institution | Role |
| Liam | Smeeth | Faculty of Epidemiology and Population Health / Department Non-communicable disease epidemiology | London School of Hygiene & Tropical Medicine, London, United Kingdom | Data creator |
| Alexander | Perkins | Faculty of Epidemiology and Population Health / Department of Medical Statistics | London School of Hygiene & Tropical Medicine, London, United Kingdom | Data Creator |
| Elizabeth | Williamson | Faculty of Epidemiology and Population Health / Department of Medical Statistics | London School of Hygiene & Tropical Medicine, London, United Kingdom | Code creator |
| Filename | Description | File format | Access status | Licence |
| SW_demographic_data | Statinwise demographic dataset | Comma Separated Values (CSV) | Controlled | Data sharing agreement |
| SW_patient_flow_data | Statinwise patient flow dataset | Comma Separated Values (CSV) | Controlled | Data sharing agreement |
| SW_primary_vas_data | Statinwise primary vas dataset | Comma Separated Values (CSV) | Controlled | Data sharing agreement |
| SW_secondary_questionnaire_data | Statinwise secondary questionnaire dataset | Comma Separated Values (CSV) | Controlled | Data sharing agreement |
| Key_analyses | Stata do-file that performs the key analyses of the StatinWISE trial using the shared data | Stata DO-file | Open | Creative Commons Attribution |
| SW_demographic_codebook | Codebook for Statinwise demographic dataset | HTML | Open | Creative Commons Attribution |
| SW_patient_flow_codebook | Codebook for the Statinwise patient flow dataset | HTML | Open | Creative Commons Attribution |
| SW_primary_vas_codebook | Codebook for the primary VAS dataset | HTML | Open | Creative Commons Attribution |
| SW_secondary_questionnaire_codebook | Codebook for the secondary questionnaire dataset | HTML | Open | Creative Commons Attribution |