https://doi.org/10.17037/DATA.00001695
Statins are one of the most commonly prescribed drugs in the United Kingdom. There is strong evidence that they are effective in safely reducing heart disease. However, there is some doubt about whether statins cause muscle pain, stiffness or weakness. The StatinWISE study sought to understand the effect of statins on muscle symptoms. The study recruited 200 volunteers from across England and Wales who had either recently stopped taking statins due to muscle symptoms, or were considering stopping due to muscle symptoms.
The Statinwise datasets are made available through an application process. Applicants must outline their proposed research and provide proof of ethical approval for the work.
| Variable Name | Variable Label | Answer Label | Answer Code | Variable Type |
| share_pid | Unique patient ID for shared data | Open ended | Numeric | |
| period | Treatment period (1-6) | Open ended | Numeric | |
| seq_num | Randomised sequence, numerical version | long | ||
| PSPSPS | 1 | |||
| PSPSSP | 2 | |||
| PSSPPS | 3 | |||
| PSSPSP | 4 | |||
| SPPSPS | 5 | |||
| SPPSSP | 6 | |||
| SPSPPS | 7 | |||
| SPSPSP | 8 | |||
| treat | Randomised treatment for this period | Numeric | ||
| Placebo | 0 | |||
| Statin | 1 | |||
| adherence | Self-reported period-level adherence to randomised medication | Numeric | ||
| Not at all | 1 | |||
| Some days | 2 | |||
| Most days | 3 | |||
| Every day | 4 | |||
| muscle_symptoms | Participant experienced muscle symptoms this period (period-level qn) | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Missing | ||||
| muscle_symptoms_cause | Participant believes muscle symptoms this period were due to study meds | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Don't know | 2 | |||
| NA | ||||
| Missing | ||||
| muscle_symptoms_restrict | Experienced muscle symptoms this period NOT attributed to another cause | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| nonadhere_forgot | Non-adherence reason: I forgot to take my study medication | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| NA | ||||
| nonadhere_othermed | Non-adherence reason: I was prescribed another medication, GP recommended | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| NA | ||||
| nonadhere_gpsymp | Non-adherence reason: Muscle symptoms, GP recommended | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| NA | ||||
| nonadhere_selfsymp | Non-adherence reason: Muscle symptoms, personal decision | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| NA | ||||
| nonadhere_want | Non-adherence reason: I didn't want to take it | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| NA | ||||
| nonadhere_other | Non-adherence reason: Other | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| NA | ||||
| vas_activity | Effect of symptoms on daily activity | Numeric | ||
| No interference | 0 | |||
| Complete interference | 10 | |||
| NA | ||||
| vas_mood | Effect of symptoms on mood | Numeric | ||
| No interference | 0 | |||
| Complete interference | 10 | |||
| NA | ||||
| vas_walk | Effect of symptoms on walking | Numeric | ||
| No interference | 0 | |||
| Complete interference | 10 | |||
| NA | ||||
| vas_work | Effect of symptoms on work | Numeric | ||
| No interference | 0 | |||
| Complete interference | 10 | |||
| NA | ||||
| vas_relations | Effect of symptoms on relations | Numeric | ||
| No interference | 0 | |||
| Complete interference | 10 | |||
| NA | ||||
| vas_sleep | Effect of symptoms on sleep | Numeric | ||
| No interference | 0 | |||
| Complete interference | 10 | |||
| NA | ||||
| vas_enjoy | Effect of symptoms on enjoyment | Numeric | ||
| No interference | 0 | |||
| Complete interference | 10 | |||
| NA | ||||
| pain_location | Main location of pain, if experienced | long | ||
| Head and Neck | 1 | |||
| Lower Limbs | 2 | |||
| Trunk | 3 | |||
| Upper Limbs | 4 | |||
| NA | ||||
| Missing | ||||
| pain_location_multiple | Pain appears in multiple locations | long | ||
| Yes | 1 | |||
| NA | ||||
| other_symptoms | Other symptoms that participant believes were due to study meds | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| Don't know | 2 | |||
| NA | ||||
| Missing | ||||
| itt_muscle_symptoms | 1+ statin VAS and 1+ placebo VAS, variable muscle_symptoms | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| itt_muscle_symptoms_restrict | 1+ statin VAS and 1+ placebo VAS, variable muscle_symptoms_restrict | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| itt_vas_activity | 1+ statin VAS and 1+ placebo VAS, variable vas_activity | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| itt_vas_mood | 1+ statin VAS and 1+ placebo VAS, variable vas_mood | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| itt_vas_walk | 1+ statin VAS and 1+ placebo VAS, variable vas_walk | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| itt_vas_work | 1+ statin VAS and 1+ placebo VAS, variable vas_work | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| itt_vas_relations | 1+ statin VAS and 1+ placebo VAS, variable vas_relations | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| itt_vas_sleep | 1+ statin VAS and 1+ placebo VAS, variable vas_sleep | Numeric | ||
| No | 0 | |||
| Yes | 1 | |||
| itt_vas_enjoy | 1+ statin VAS and 1+ placebo VAS, variable vas_enjoy | Numeric | ||
| No | 0 | |||
| Yes | 1 |