https://doi.org/10.17037/DATA.00001695
Statins are one of the most commonly prescribed drugs in the United Kingdom. There is strong evidence that they are effective in safely reducing heart disease. However, there is some doubt about whether statins cause muscle pain, stiffness or weakness. The StatinWISE study sought to understand the effect of statins on muscle symptoms. The study recruited 200 volunteers from across England and Wales who had either recently stopped taking statins due to muscle symptoms, or were considering stopping due to muscle symptoms.
The Statinwise datasets are made available through an application process. Applicants must outline their proposed research and provide proof of ethical approval for the work.
| Variable Name | Variable Label | Answer Label | Answer Code | Variable Type |
| share_pid | Unique patient ID for shared data | Open ended | Numeric | |
| seq_num | Randomised sequence, numerical version | long | ||
| PSPSPS | 1 | |||
| PSPSSP | 2 | |||
| PSSPPS | 3 | |||
| PSSPSP | 4 | |||
| SPPSPS | 5 | |||
| SPPSSP | 6 | |||
| SPSPPS | 7 | |||
| SPSPSP | 8 | |||
| withdrawn | Patient status | Numeric | ||
| Completed | 0 | |||
| Withdrawn | 1 | |||
| noncomplete_reason | Reason for not completing 6 treatment periods | Numeric | ||
| Death | 1 | |||
| Early withdrawal | 2 | |||
| Lost to follow-up | 3 | |||
| N/A - completed | ||||
| withdrawal_reason | Reason for early withdrawal | long | ||
| a. withdrawal of informed consent | 1 | |||
| b. intolerable muscle symptoms | 2 | |||
| c. clinical concern | 3 | |||
| d. other | 4 | |||
| e. unknown | 5 | |||
| NA - no early withdrawal | ||||
| include_primary | Include in primary analysis: 1+ statin VAS and 1+ placebo VAS | Numeric | ||
| Do not include | 0 | |||
| Include | 1 | |||
| nperiod_primary | Number of periods with 1+ VAS (primary outcome measure) | Open ended | Numeric |