Beale, MA, Marks, M, Sahi, SK, Tantalo, LC, Nori, AV, French, P, Lukehart, SA, Marra, CM and Thomson, N. 2019. Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages. [Online]. Nature Communications. Available from: https://doi.org/10.1038/s41467-019-11216-7
Beale, MA, Marks, M, Sahi, SK, Tantalo, LC, Nori, AV, French, P, Lukehart, SA, Marra, CM and Thomson, N. Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages. [Internet] LSHTM Data Compass. Nature Communications; 2019. Available from: https://doi.org/10.1038/s41467-019-11216-7
Beale, MA, Marks, M, Sahi, SK, Tantalo, LC, Nori, AV, French, P, Lukehart, SA, Marra, CM and Thomson, N (2019). Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages. [Data Collection]. Nature Communications. https://doi.org/10.1038/s41467-019-11216-7
Description
Syphilis is a sexually transmitted infection caused by Treponema pallidum subspecies pallidum and may lead to severe complications. Recent years have seen striking increases in syphilis in many countries. Previous analyses have suggested one lineage of syphilis, SS14, may have expanded recently, indicating emergence of a single pandemic azithromycin-resistant cluster. Here we use direct sequencing of T. pallidum combined with phylogenomic analyses to show that both SS14- and Nichols-lineages are simultaneously circulating in clinically relevant populations in multiple countries. We correlate the appearance of genotypic macrolide resistance with multiple independently evolved SS14 sub-lineages and show that genotypically resistant and sensitive sub-lineages are spreading contemporaneously. These findings inform our understanding of the current syphilis epidemic by demonstrating how macrolide resistance evolves in Treponema subspecies and provide a warning on broader issues of antimicrobial resistance.
| Data capture method | Experiment |
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| Date (Published in a 3rd party system) | 22 July 2019 |
| Language(s) of written materials | English |
| Data Creators | Beale, MA, Marks, M, Sahi, SK, Tantalo, LC, Nori, AV, French, P, Lukehart, SA, Marra, CM and Thomson, N |
|---|---|
| LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
| Participating Institutions | London School of Hygiene & Tropical Medicine |
| Funders |
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| Depositor | Heather Rayner |
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| Date Deposited | 31 Jul 2019 09:16 |
| Last Modified | 31 Jul 2019 09:16 |
| Publisher | Nature Communications |
