Table 1.
        Factors associated with T-SPOT. TB among five year old children vaccinated with BCG in infancy.
Factora,TB infection,Crude OR (95% CI),P,Adjusted OR (95% CI) and ,P
Positive (%),Negative (%)
Socio-demographic characteristics
Maternal age at enrolment,,,1.02 (0.98–1.06),0.27,,
Parity,,,1.11 (0.99–1.26),0.08,1.10 (0.95–1.27),0.21
Maternal education
 None/primary,34 (7.4),425 (92.6),1,,,
 Secondary/tertiary,41 (9.7),384 (90.4),1.33 (0.83–2.15),0.23,,
Household SES,,,0.92 (0.76–1.12),0.41,,
Household crowding,,,1.14 (0.96–1.36),0.14,1.03 (0.83–1.27),0.80
Location of residence,,,,,,
 Urban,59 (10.5),505 (89.5),1,,1,
 Rural,16 (5.1),300 (94.9),0.46 (0.26–0.81),0.01,0.39 (0.19–0.78),0.01
Maternal characteristics
Schistosoma mansoni,,,,,,
 No,58 (8.3),645 (91.8),1,,,
 Yes,17 (9.6),161 (90.5),1.17 (0.67–2.07),0.58,,
Hookworm,,,,,,
 No,45 (8.6),478 (91.4),1,,,
 Yes,30 (8.4),328 (91.6),0.97 (0.60–1.57),0.91,,
Mansonella perstans,,,,,,
 No,59 (8.4),644 (91.6),1,,,
 Yes,16 (8.7),167 (91.3),1.05 (0.59–1.86),0.88,,
Malaria,,,,,,
 No,70 (8.9),717 (91.1),1,,,
 Yes,4 (4.8),79 (95.2),0.52 (0.18–1.46),0.21,,
Maternal TB exposure,,,,,,
 No,65 (8.2),723 (91.8),1,,,
 Yes,9 (9.8),83 (90.2),1.21 (0.58–2.51),0.62,,
Maternal BCG scar,,,,,,
 No,27 (7.5),332 (92.5),1,,,
 Yes,46 (9.3),449 (90.7),1.26 (0.77–2.07),0.36,,
Child characteristics,,,,,,
Sex,,,,,,
 Male,30 (7.9),350 (92.1),1,,,
 Female,36 (9.9),328 (90.1),1.28 (0.77–2.13),0.34,,
Birth weight,,,1.03 (0.59–1.82),0.91,,
HIV status,,,,,,
 Unexposed,64 (8.0),737 (92.0),1,,,
 Exposed-uninfected,9 (12.9),61 (87.1),1.70 (0.81–3.58),,,
 Infected,2 (15.4),11 (84.6),2.09 (0.45–9.65),0.30,,
BCG scar,,,,,,
 No,29 (8.6),307 (91.4),1,,,
 Yes,41 (9.5),391 (90.5),1.11 (0.67–1.83),0.68,,
BCG vaccine strain,,,,,,
 Russia,53 (10.1),471 (89.9),1,,1,
 Bulgaria,13 (5.2),237 (94.8),0.49 (0.26–0.91),,0.73 (0.35–1.51),
 Danish,6 (6.7),84 (93.3),0.63 (0.26–1.52),0.05,2.25 (0.82–6.22),0.17
History of TB contact/disease,,,,,,
 No,60 (7.5),740 (92.5),1,,1,
 Yes,15 (17.4),71 (82.6),2.61 (1.41–4.82),<0.01,2.16 (1.02–4.55),0.04
Any helminth infection ≤5 years,,,,,,
 No,63 (8.8),652 (91.2),1,,,
 Yes,12 (7.0),159 (93.0),0.78 (0.41–1.48),0.45,,
WHZ score<comma> age 5,,,0.95 (0.77–1.18),0.67,,
HAZ score<comma> age 5,,,1.19 (0.96–1.49),0.11,1.10 (0.86–1.40),0.44
WAZ score<comma> age 5,,,1.15 (0.86–1.53),0.36,,
Asymptomatic malaria<comma> age 5,,,,,,
 No,73 (8.9),752 (91.1),1,,,
 Yes,1 (2.9),34 (97.1),0.30 (0.04–2.25),0.24,,
Number of malaria events,,,0.96 (0.86–1.07),0.46,,
Number of diarrhoea events,,,1.03 (0.96–1.12),0.40,,
Number of LRTI events,,,1.12 (0.92–1.36),0.26,,
Age of infection with CMV,,,0.73 (0.43–1.23),0.23,,
Age of infection with HSV,,,1.19 (0.91–1.55),0.22,,
Trial interventions,,,,,,
Maternal albendazole treatment,,,,,,
No,39 (8.8),406 (91.2),1,,,
Yes,36 (8.2),405 (91.8),0.93 (0.57–1.49),0.75,,
Maternal praziquantel treatment,,,,,,
 No,35 (7.6),426 (92.4),1,,,
 Yes,40 (9.4),385 (90.6),1.26 (0.79–2.03),0.33,,
Childhood albendazole treatment,,,,,,
 No,37 (8.2),414 (91.8),1,,,
 Yes,38 (8.8),395 (91.2),1.08 (0.67–1.73),0.76,,