Supplementary Table S1.  Weather characteristics of all included INTERACT2 cities ,,,,,,,
,Patient,Temperature characteristics during study period (°C)a,,,,,
,number,,,,,,
Country/City,N (%),Mean (SD) ,Median,Min,Max,25%,75%
Argentina,,,,,,,
Adrogue,1 (0.1),17 (7),17,-4,39,12,22
Mendoza,3 (0.2),18 (8),18,-5,43,12,24
Australia,,,,,,,
Brisbane,3 (0.2),20 (5),21,4,39,17,24
Gosford,21 (1.1),16 (6),17,-1,41,12,21
Newcastle,10 (0.5),17 (6),18,0,42,13,21
Sydney,4 (0.2),18 (5),18,4,41,15,22
Melbourne,30 (1.5),16 (6),15,2,44,12,19
Perth,3 (0.2),19 (6),18,3,48,15,22
Austria,,,,,,,
Linz,9 (0.5),10 (9),10,-19,37,3,17
Innsbruck,34 (1.7),9 (9),9,-18,35,2,16
Graz,20 (1.0),10 (9),11,-18,35,3,18
Belgium,,,,,,,
Brussels,12 (0.6),11 (7),10,-14,34,6,15
Brazil,,,,,,,
Rio de Janeiro,1 (0.1),24 (4),24,11,40,21,27
Sao Paulo,10 (0.5),20 (5),20,3,36,17,23
Curitiba,1 (0.1),18 (5),17,-1,35,14,21
Porto Alegre,5 (0.3),19 (6),19,-3,39,15,23
Chile,,,,,,,
Santiago ,17 (0.9),15 (7),14,-4,36,10,20
Los Angeles,12 (0.6),12 (6),11,-5,37,8,15
China,,,,,,,
Changchun,73 (3.7),5 (15),7,-34,37,-8,19
Beijing,280 (14.0),12 (12),14,-19,41,1,23
Tangshan,225 (11.3),12 (12),14,-19,41,1,23
Cangzhou,158 (7.9),13 (12),14,-18,39,2,23
Shijiazhuang,83 (4.2),11 (12),12,-18,40,1,20
Tianjin,53 (2.7),13 (12),14,-18,39,2,23
Suzhou,41 (2.1),17 (10),18,-6,39,9,25
Shanghai,93 (4.7),17 (10),18,-6,39,9,25
Nanjing,18 (0.9),16 (10),17,-11,39,7,25
Wuxi,4 (0.2),16 (10),17,-11,39,7,25
Changsha,71 (3.6),18 (10),19,-6,41,9,26
Fuzhou,12 (0.6),20 (7),21,1,36,14,27
Zengcheng,15 (0.8),23 (7),25,2,40,18,28
Guangzhou,38 (1.9),23 (7),25,2,40,18,28
Zhuhai,26 (1.3),24 (6),25,5,36,20,29
Hong Kong (SAR),1 (0.1),24 (6),25,5,36,20,29
Finland,,,,,,,
Helsinki,36 (1.8),6 (10),6,-31,34,0,13
France,,,,,,,
Lille,30 (1.5),11 (7),11,-12,35,6,16
Calais,12 (0.6),11 (6),11,-10,32,7,15
Paris,143 (7.2),12 (7),12,-12,37,7,17
Le Chesnay,16 (0.8),11 (7),11,-13,37,6,16
Blain,13 (0.7),12 (7),12,-8,36,8,17
Germany,,,,,,,
Hamburg,2 (0.1),10 (8),10,-17,34,4,15
Berlin,45 (2.3),10 (8),10,-19,37,4,16
Halle,21 (1.1),10 (9),10,-21,37,4,16
Dresden,27 (1.4),10 (9),10,-20,37,4,16
Dusseldorf,3 (0.2),11 (7),11,-14,37,6,16
Frankfurt,11 (0.6),11 (8),11,-16,36,5,17
Mannheim,23 (1.2),12 (8),11,-15,37,6,18
Ulm,7 (0.4),9 (8),9,-19,33,2,15
India,,,,,,,
Hyderabad,10 (0.5),23 (9),24,-5,43,17,29
Chennai,1 (0.1),28 (4),28,17,42,26,31
Italy,,,,,,,
Modena,15 (0.8),14 (9),14,-15,38,6,21
Perugia,22 (1.1),14 (9),14,-9,40,8,20
Rome,10 (0.5),16 (8),16,-6,39,10,22
Netherlands,,,,,,,
Utrecht,2 (0.1),11 (7),11,-16,34,6,16
Norway,,,,,,,
Tromso,1 (0.1),3 (6),3,-17,29,-1,8
Lillehammer,2 (0.1),2 (9),2,-33,28,-4,9
Kristiansand,2 (0.1),7 (8),8,-23,28,2,13
Pakistan,,,,,,,
Karachi,9 (0.5),27 (6),28,2,44,24,30
Portugal,,,,,,,
Oporto,22 (1.1),15 (5),15,-3,38,12,18
Spain,,,,,,,
Girona,34 (1.7),15 (8),14,-8,37,9,20
Barcelona,10 (0.5),17 (6),16,-1,34,12,22
United Kingdom,,,,,,,
Ashington,2 (0.1),9 (6),9,-11,27,5,13
Newcastle upon  Tyne,8 (0.4),9 (6),9,-11,27,5,13
Durham,1 (0.1),9 (6),9,-11,27,5,13
Leeds,2 (0.1),9 (6),9,-12,27,5,13
Salford,12 (0.6),10 (5),10,-12,29,7,14
Nottingham,2 (0.1),10 (6),10,-13,29,6,14
Stafford,2 (0.1),10 (6),10,-19,28,6,14
Wolverhampton,4 (0.2),10 (6),10,-19,28,6,14
Leicester,3 (0.2),10 (6),10,-13,29,6,14
Cambridge,1 (0.1),10 (6),11,-11,31,6,15
Oxford,3 (0.2),10 (6),10,-17,30,6,15
Bristol,1 (0.1),10 (6),10,-8,28,6,14
Bath,6 (0.3),10 (6),10,-8,28,6,14
London,16 (0.8),12 (6),12,-9,32,7,16
Taunton,1 (0.1),10 (6),11,-15,28,7,15
Exeter,3 (0.2),10 (6),11,-15,28,7,15
Bournemouth,3 (0.2),11 (6),11,-11,29,7,15
USA,, ,,,,,
 Rochester,11 (0.6),7 (13),8,-32,38,-2,18
Total,1997 (100),13 (9),13,-34,48,7,19
aFrom 01/01/2008 to 01/01/2013,,,,,,,