Records of human cases of Buruli ulcer collated through literature review and from surveillance programmes by national control programmes. For details on the review methodology, see Simpson et al 2019: Mapping the global distribution of Buruli ulcer: a systematic review with evidence consensus.
The surveillance datasets were compiled through routine surveillance for Buruli ulcer in Cameroon, Ghana, Nigeria and Togo.
Peer-reviewed literature was identified from searches of PubMed and Web of Science databases, updated on 06/08/2018. Additional publications were identified from reference lists of identified papers. We used the search terms (OR): “Buruli ulcer*”, (“Mycob* AND ulcer*”), “Bairnsdale ulcer”. There were no limits on publication date, study type, or location. We included English, French, and Spanish language publications. Publications were eligible for inclusion if they reported geographical locations with evidence of M. ulcerans infection in humans or animals, or detection of M. ulcerans in animal and environmental samples. There were no limits on publication date, participant population, study type or location. Articles that did not report original data were excluded. Studies that recruited patients from health facilities or used strains of M. ulcerans isolated from clinical samples were included in the evidence consensus framework only if patients’ home addresses were provided. Cases with recorded travel history to several endemic regions were excluded. If a dataset was duplicated in numerous papers, the most comprehensive was included.
For full details on literature review methodology, please see Simpson et al. 2019: Mapping the global distribution of Buruli ulcer: a systematic review with evidence consensus. Data contributed by the programme for National Yaws, Leishmaniasis, Leprosy and Buruli ulcer Control Programme in Cameroon are under the ownership of the Ministry of Health in Cameroon and their use is subject to the approval of the Ministry of Health.
Occurrences of Mycobacterium ulcerans in animals and environmental samples
| Field name | Description |
| Occurrence_ID | Unique identifier assigned to record in data extratction |
| source_type | Source of record: LIT = literature review, NPR = national programme surveillance data |
| ADM0_NAME | Country name |
| ISO_code3 | Country ISO code |
| ADM1_NAME | First-order administrative divisions name according to GADM https://gadm.org |
| GADM1_ID | First-order administrative divisions ID according to GADM https://gadm.org |
| ADM2_NAME | Second-order administrative divisions name according to GADM https://gadm.org |
| GADM2_ID | Second-order administrative divisions ID according to GADM https://gadm.org |
| Location_name | Name of location given in source |
| lat | latitude of location |
| long | longitude of location |
| Geo_reliability | Reliability of georeferenced location:
|
| max_year | Year of sample as given in source (maximum if range given) |
| N_positive | Number of positive results for location as given in source (maximum if range given) |
| higher_taxon | higher taxon for animal samples |
| lower_taxon | most specific taxonomic level given |
| Sample_type | type of sample: aquatic animal; aquatic non-animal; terrestrial vertebrate- clinical; terrestrial invertebrate; terrestrial vertebrate- faeces; terrestrial vertebrate- clinical; terrestrial non-animal; |
| PCR_Test | PCR target reported |
| ER_result | reported result of PCR targeting endoreticulase gene |
| KR_result | reported result of PCR targeting ketoreductase gene |
| IS2404_result | reported result of PCR targeting insertion sequence 2404 |
| 16SrRNAresults | reported result of PCR targeting 16S RNA sequence |
| 16S_23S ITS | reported result of PCR targeting 16s-23s internal transcribed spacer region |
| IS2606_result | reported result of PCR targeting insertion sequence 2606 |
| VNTR_MIRU_result_MU | reported results of variable nucleotide tandem repeat typing for M. ulcerans |
| VNTR_result_MPM | reported results of variable nucleotide tandem repeat typing for mycolactone producing mycobacteria |
| qPCR_confirmed | reported results of quantitative PCR to confirm M. ulcerans |
| other tests | other tests reported |
| other results | reported results of other tests |
| MU_confirmed | DNA or organism confirmed as M. ulcerans (yes or no) |
Occurrences of Buruli ulcer infections in humans.
| Occurrence_ID | Unique identifier assigned to record in data extratction |
| source_type | Source of record: LIT = literature review, NPR = national programme surveillance data |
| ADM0_NAME | Country name |
| ISO_code3 | Country ISO code |
| ADM1_NAME | First-order administrative divisions name according to GADM https://gadm.org |
| GADM1_ID | First-order administrative divisions ID according to GADM https://gadm.org |
| ADM2_NAME | Second-order administrative divisions name according to GADM https://gadm.org |
| GADM2_ID | Second-order administrative divisions ID according to GADM https://gadm.org |
| Location_name | Name of location given in source |
| lat | latitude of location |
| long | longitude of location |
| Geo_reliability | Reliability of georeferenced location:
|
| max_year | Year case reported as given in source (maximum if range given) |
| number | Number case reported as given in source (maximum if range given) |
| Clinical_dxo | Clinical diganosis reported (yes/no/ns) |
| Ziehl_Neelsen_stain | Ziehl Neelsen stain reported (yes/no/mixed/ns) |
| ZN_result | Ziehl Neelsen result (number positive, or reported result) |
| Culture | Clinical diganosis reported (yes/no/ns) |
| Culture_result | Culture result (number positive, or reported result) |
| Histo | Clinical diganosis reported (yes/no/ns) |
| histo_result | Histopathological result (number positive, or reported result) |
| PCR_Test | Clinical diganosis reported (yes/no/ns) |
| PCR_result | PCR result (number positive, or reported result) |