Colonization factors among enterotoxigenic Escherichia coli isolates from children with moderate-to-severe diarrhea and from matched controls in the Global Enteric Multicenter Study (GEMS)
Torres, AG, Vidal, RM, Muhsen, K, Tennant, SM, Svennerholm, A, Sow, SO, Sur, D, Zaidi, AKM, Faruque, ASG, Saha, D, Adegbola, R, Hossain, MJ, Alonso, PL, Breiman, RF, Bassat, Q, Tamboura, B, Sanogo, D, Onwuchekwa, U, Manna, B, Ramamurthy, T, Kanungo, S, Ahmed, S, Qureshi, S, Quadri, F, Hossain, A, Das, SK, Antonio, M, Mandomando, I, Nhampossa, T, Acácio, S, Omore, R, Ochieng, JB, Oundo, JO, Mintz, ED, O’Reilly, CE, Berkeley, LY, Livio, S, Panchalingam, S, Nasrin, D, Farag, TH, Wu, Y, Sommerfelt, H, Robins-Browne, RM, Del Canto, F, Hazen, TH, Rasko, DA, Kotloff, KL, Nataro, JP and Levine, MM.
2019.
Colonization factors among enterotoxigenic Escherichia coli isolates from children with moderate-to-severe diarrhea and from matched controls in the Global Enteric Multicenter Study (GEMS).
[Online].
PLoS Neglected Tropical Diseases.
Available from:
https://doi.org/10.1371/journal.pntd.0007037
Torres, AG, Vidal, RM, Muhsen, K, Tennant, SM, Svennerholm, A, Sow, SO, Sur, D, Zaidi, AKM, Faruque, ASG, Saha, D, Adegbola, R, Hossain, MJ, Alonso, PL, Breiman, RF, Bassat, Q, Tamboura, B, Sanogo, D, Onwuchekwa, U, Manna, B, Ramamurthy, T, Kanungo, S, Ahmed, S, Qureshi, S, Quadri, F, Hossain, A, Das, SK, Antonio, M, Mandomando, I, Nhampossa, T, Acácio, S, Omore, R, Ochieng, JB, Oundo, JO, Mintz, ED, O’Reilly, CE, Berkeley, LY, Livio, S, Panchalingam, S, Nasrin, D, Farag, TH, Wu, Y, Sommerfelt, H, Robins-Browne, RM, Del Canto, F, Hazen, TH, Rasko, DA, Kotloff, KL, Nataro, JP and Levine, MM.
Colonization factors among enterotoxigenic Escherichia coli isolates from children with moderate-to-severe diarrhea and from matched controls in the Global Enteric Multicenter Study (GEMS)
[Internet].
PLoS Neglected Tropical Diseases;
2019.
Available from:
https://doi.org/10.1371/journal.pntd.0007037
Torres, AG, Vidal, RM, Muhsen, K, Tennant, SM, Svennerholm, A, Sow, SO, Sur, D, Zaidi, AKM, Faruque, ASG, Saha, D, Adegbola, R, Hossain, MJ, Alonso, PL, Breiman, RF, Bassat, Q, Tamboura, B, Sanogo, D, Onwuchekwa, U, Manna, B, Ramamurthy, T, Kanungo, S, Ahmed, S, Qureshi, S, Quadri, F, Hossain, A, Das, SK, Antonio, M, Mandomando, I, Nhampossa, T, Acácio, S, Omore, R, Ochieng, JB, Oundo, JO, Mintz, ED, O’Reilly, CE, Berkeley, LY, Livio, S, Panchalingam, S, Nasrin, D, Farag, TH, Wu, Y, Sommerfelt, H, Robins-Browne, RM, Del Canto, F, Hazen, TH, Rasko, DA, Kotloff, KL, Nataro, JP and Levine, MM
(2019).
Colonization factors among enterotoxigenic Escherichia coli isolates from children with moderate-to-severe diarrhea and from matched controls in the Global Enteric Multicenter Study (GEMS).
[Data Collection].
PLoS Neglected Tropical Diseases.
https://doi.org/10.1371/journal.pntd.0007037
Description
Enterotoxigenic Escherichia coli (ETEC) encoding heat-stable enterotoxin (ST) alone or with heat-labile enterotoxin (LT) cause moderate-to-severe diarrhea (MSD) in developing country children. The Global Enteric Multicenter Study (GEMS) identified ETEC encoding ST among the top four enteropathogens. Since the GEMS objective was to provide evidence to guide development and implementation of enteric vaccines and other interventions to diminish diarrheal disease morbidity and mortality, we examined colonization factor (CF) prevalence among ETEC isolates from children age <5 years with MSD and from matched controls in four African and three Asian sites. We also assessed strength of association of specific CFs with MSD.
