Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa

Gurdasani, D, Carstensen, T, Fatumo, S, Chen, G, Franklin, CS, Prado-Martinez, J, Bouman, H, Abascal, F, Haber, M, Tachmazidou, I, Mathieson, I, Ekoru, K, DeGorter, MK, Nsubuga, RN, Finan, C, Wheeler, E, Chen, L, Cooper, DN, Schiffels, S, Chen, Y, Ritchie, GR, Pollard, MO, Fortune, MD, Mentzer, AJ, Garrison, E, Bergström, A, Hatzikotoulas, K, Adeyemo, A, Doumatey, A, Elding, H, Wain, LV, Ehret, G, Auer, PL, Kooperberg, CL, Reiner, AP, Franceschini, N, Maher, DP, Montgomery, SB, Kadie, C, Widmer, C, Xue, Y, Seeley, J, Asiki, G, Kamali, A, Young, EH, Pomilla, C, Soranzo, N, Zeggini, E, Pirie, F, Morris, AP, Heckerman, D, Tyler-Smith, C, Motala, A, Rotimi, C, Kaleebu, P, Barroso, I and Sandhu, MS. 2019. Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa. [Online]. Cell. Available from: https://doi.org/10.1016/j.cell.2019.10.004

Gurdasani, D, Carstensen, T, Fatumo, S, Chen, G, Franklin, CS, Prado-Martinez, J, Bouman, H, Abascal, F, Haber, M, Tachmazidou, I, Mathieson, I, Ekoru, K, DeGorter, MK, Nsubuga, RN, Finan, C, Wheeler, E, Chen, L, Cooper, DN, Schiffels, S, Chen, Y, Ritchie, GR, Pollard, MO, Fortune, MD, Mentzer, AJ, Garrison, E, Bergström, A, Hatzikotoulas, K, Adeyemo, A, Doumatey, A, Elding, H, Wain, LV, Ehret, G, Auer, PL, Kooperberg, CL, Reiner, AP, Franceschini, N, Maher, DP, Montgomery, SB, Kadie, C, Widmer, C, Xue, Y, Seeley, J, Asiki, G, Kamali, A, Young, EH, Pomilla, C, Soranzo, N, Zeggini, E, Pirie, F, Morris, AP, Heckerman, D, Tyler-Smith, C, Motala, A, Rotimi, C, Kaleebu, P, Barroso, I and Sandhu, MS. Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa [Internet]. Cell; 2019. Available from: https://doi.org/10.1016/j.cell.2019.10.004

Gurdasani, D, Carstensen, T, Fatumo, S, Chen, G, Franklin, CS, Prado-Martinez, J, Bouman, H, Abascal, F, Haber, M, Tachmazidou, I, Mathieson, I, Ekoru, K, DeGorter, MK, Nsubuga, RN, Finan, C, Wheeler, E, Chen, L, Cooper, DN, Schiffels, S, Chen, Y, Ritchie, GR, Pollard, MO, Fortune, MD, Mentzer, AJ, Garrison, E, Bergström, A, Hatzikotoulas, K, Adeyemo, A, Doumatey, A, Elding, H, Wain, LV, Ehret, G, Auer, PL, Kooperberg, CL, Reiner, AP, Franceschini, N, Maher, DP, Montgomery, SB, Kadie, C, Widmer, C, Xue, Y, Seeley, J, Asiki, G, Kamali, A, Young, EH, Pomilla, C, Soranzo, N, Zeggini, E, Pirie, F, Morris, AP, Heckerman, D, Tyler-Smith, C, Motala, A, Rotimi, C, Kaleebu, P, Barroso, I and Sandhu, MS (2019). Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa. [Data Collection]. Cell. https://doi.org/10.1016/j.cell.2019.10.004

Description

Genomic studies in African populations provide unique opportunities to understand disease etiology, human diversity, and population history. In the largest study of its kind, comprising genome-wide data from 6,400 individuals and whole-genome sequences from 1,978 individuals from rural Uganda, we find evidence of geographically correlated fine-scale population substructure. Historically, the ancestry of modern Ugandans was best represented by a mixture of ancient East African pastoralists. We demonstrate the value of the largest sequence panel from Africa to date as an imputation resource. Examining 34 cardiometabolic traits, we show systematic differences in trait heritability between European and African populations, probably reflecting the differential impact of genes and environment. In a multi-trait pan-African GWAS of up to 14,126 individuals, we identify novel loci associated with anthropometric, hematological, lipid, and glycemic traits. We find that several functionally important signals are driven by Africa-specific variants, highlighting the value of studying diverse populations across the region.

Methods

Data capture method	Aggregation
Date (Date published in a 3rd party system)	31 October 2019
Language(s) of written materials	English

People & Groups

Data Creators	Gurdasani, D, Carstensen, T, Fatumo, S, Chen, G, Franklin, CS, Prado-Martinez, J, Bouman, H, Abascal, F, Haber, M, Tachmazidou, I, Mathieson, I, Ekoru, K, DeGorter, MK, Nsubuga, RN, Finan, C, Wheeler, E, Chen, L, Cooper, DN, Schiffels, S, Chen, Y, Ritchie, GR, Pollard, MO, Fortune, MD, Mentzer, AJ, Garrison, E, Bergström, A, Hatzikotoulas, K, Adeyemo, A, Doumatey, A, Elding, H, Wain, LV, Ehret, G, Auer, PL, Kooperberg, CL, Reiner, AP, Franceschini, N, Maher, DP, Montgomery, SB, Kadie, C, Widmer, C, Xue, Y, Seeley, J, Asiki, G, Kamali, A, Young, EH, Pomilla, C, Soranzo, N, Zeggini, E, Pirie, F, Morris, AP, Heckerman, D, Tyler-Smith, C, Motala, A, Rotimi, C, Kaleebu, P, Barroso, I and Sandhu, MS
LSHTM Faculty/Department	Faculty of Public Health and Policy > Dept of Global Health and Development
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom