Persistence of Innate Immune Pathways in Late Stage Human Bacterial and Fungal Keratitis: Results from a Comparative Transcriptome Analysis

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Chidambaram, JD, Kannambath, S, Srikanthi, P, Shah, M, Lalitha, P, Elakkiya, S, Bauer, J, Prajna, NV, Holland, MJ and Burton, MJ. 2017. Persistence of Innate Immune Pathways in Late Stage Human Bacterial and Fungal Keratitis: Results from a Comparative Transcriptome Analysis. [Online]. Frontiers in Cellular and Infection Microbiology. Available from: - http://journal.frontiersin.org/article/10.3389/fcimb.2017.00193/full#supplementary-material

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Tabular data associated with a comparative Transcriptome analysis of Innate Immune Pathways in Late Stage Human Bacterial and Fungal Keratitis. This includes details of primers used for RTqPCR TLDA Experiment; demographic, clinical, and microbiological data for microarray participants; a list of differentially expressed genes, fold changes, and false-discovery rate (FDR) adjusted p-values in the three microarray pairwise comparisons (FK vs. C, BK vs. C, and BK vs. FK); gene ontology enrichment analysis for the differentially expressed genes common to both bacterial and fungal keratitis: biological process (BP_FAT), molecular function (MF_FAT), and cellular component (CC_FAT) terms from DAVID v6.8; gene ontology term enrichment analysis for each of the seven most highly connected gene clusters in the network co-expression analysis (using DAVID v6.8). Normalized expression intensities of all differentially expressed genes in the bacterial and fungal keratitis vs. control comparisons used to create network graph in Miru).; and a comparison of early stage samples from the validation cohort (symptom duration ≤7 days) with microarray tissue samples.

Published in a 3rd party system Date: 18 May 2017
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Mode of data capture
Lab observation
Data Creators(s): Chidambaram, JD, Kannambath, S, Srikanthi, P, Shah, M, Lalitha, P, Elakkiya, S, Bauer, J, Prajna, NV, Holland, MJ and Burton, MJ
LSHTM Faculty/Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Participating Institutions: London School of Hygiene and Tropical Medicine, London, United Kingdom, St. George's University of London, London, United Kingdom, Aravind Eye Hospital, Madurai, India, Aravind Medical Research Foundation, Madurai, India, University of Cambridge, Cambridge, United Kingdom

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