CRASH - Corticosteroid Randomisation after Significant Head Injury

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CRASH Trial Collaborators. 2005. CRASH - Corticosteroid Randomisation after Significant Head Injury. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: 10.17037/DATA.11 https://ctu-app.lshtm.ac.uk/freebird/index.php/available-trials/

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A large simple placebo controlled trial, among adults with head injury and impaired consciousness, of the effects of a 48-hour infusion of corticosteroids on death and neurological disability. CRASH was a randomised, controlled, double-blind trial undertaken in 239 hospitals in 49 countries. A total of 10008 adults with head injury and a Glasgow Coma Score (GCS) of 14 or less within 8 hours of injury were randomly allocated 48 hour infusion of corticosteroids (methylprednisolone) or placebo. Primary outcomes were death within 2 weeks of injury or disability at 6 months. Prespecified subgroup analyses were based on injury severity (GCS) at randomisation and on time from injury to randomisation and analysis was by intention to treat.

Completed Date: May 2005
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Mode of data capture
Field observation
Data Creators(s): CRASH Trial Collaborators
LSHTM Faculty/Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Participating Institutions: London School of Hygiene & Tropical Medicine

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