"Demographics, characteristics",Incident diagnosis of Parkinson’s disease (N=692),"No Parkinson’s disease (N=164,278)"
Median age (quartiles),70. 3 (63.9-75.1),63.4 (54.2-71.7)
Range (years),24.1-92.2,7.3 – 100.3
"Sex, n (%)",,
Female,261 (37.7),"71,459 (43.5)"
Male,431 (62.3),"92,819 (56.5)"
Calendar year at indexdate,,
1999-2003,384 (55.5),"53,619 (32.6)"
2004-2008,240 (34.7),"63,321 (38.5)"
2009-2013,68 (9.8),"47,338 (28.8)"
"Alcohol use at entry study, n (%)",,
No,132 (19.1),"27,657 (16.8)"
Yes,456 (65.9),"107,458 (65.4) "
Ex,39 (5.6),"10,903 (6.6)"
Excessive,34 (4.9),"9,479 (5.8)"
Unknown,31 (4.5),"8,781 (5.4)"
"Smoking at entry study, n (%)",,
Current,87 (12.6),"29,727 (18.1)"
Ex smoker,360 (52.0),"78,164 (47.6)"
Never,236 (34.1),"53,932 (32.8)"
Unknown,9 (1.3),"2,455 (1.5)"
"Body mass index (kg/m2) at entry study, n (%)",,
< 18.5,,
18.5 – 24.9,1 (0.1),706 (0.4)
25.0 – 29.9,133 (19.2),"23,641 (14.4)"
>= 30,246 (35.6)  ,"55,265 (33.6)"
Unknown,293 (42.3),"79,622 (48.5)"
,19 (2.8),"5,044 (3.1)"
"Type of user, n (%)",,
First line monotherapy,13 (1.9),"5,279 (3.2)"
Second line monotherapy,24 (3.5),"4,926 (3.0)"
Second line combination,655 (94.6),"154,073 (93.8)"
"Co-morbidities, n (%)",,
Head injury,23 (3.3),"5,318 (3.2)"
Diabetes,,
0-2 years before entry study,125 (18.1),"41,015 (25.0)"
2-5 years before entry study,151 (21.8),"41,058 (25.0)"
5-9 years before entry study,189 (27.3),"40,936 (24.9)"
>9 years before entry study,226 (32.7),"40,808 (24.8)"
Diabetes diagnosis missing,1 (0.1),461 (0.3)
HbA1c levels,,
<7.5% (57 mmol/mol),257 (37.1)," 46,074 (28.1)"
7.6-8.3% (66 mmol/mol), 166 (24.0),"38,149  (23.2)"
8.4-9.6% (80 mmol/mol), 133 (19.2),"37,316 (22.7)"
>9.6%,129 (18.6),"40,588 (24.7)"
HbA1c missing  ,7 (1.0),"2,151 (1.3)"
"Co-medications, n (%)",,
    CCB,,
Never,413 (59.7),"106,099  (64.6)"
"Used >6 months before index, but not at index (past user)",153 (22.1),"29,945 (18.2)"
Current user for less than 1 year,,
Current user for > 1 year,24 (3.5),"    4,534 (2.8)"
HRT,102 (14.7),"23,700 (14.4)"
Never,,
"Used >6 months before index, but not at index (past user)",647 (93.5),"148,447 (90.4)"
Current user for less than 1 year,29 (4.2),"13,005 (7.9)"
Current user for > 1 year,,
,1 (0.1),390 (0.2)
,15 (2.2),"2,436 (1.5)"
,,